cyamemazine   Click here for help

GtoPdb Ligand ID: 84

Synonyms: cyamepromazine | RP-7204
Compound class: Synthetic organic
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 55.57
Molecular weight 323.15
XLogP 4.32
No. Lipinski's rules broken 0
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Canonical SMILES N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1
Isomeric SMILES N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1
InChI InChI=1S/C19H21N3S/c1-14(12-21(2)3)13-22-16-6-4-5-7-18(16)23-19-9-8-15(11-20)10-17(19)22/h4-10,14H,12-13H2,1-3H3
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
5-HT2A receptor Hs Antagonist Antagonist 8.8 pKi - 1
pKi 8.8 [1]
5-HT2C receptor Hs Antagonist Antagonist 7.9 pKi - 1
pKi 7.9 [1]
5-HT7 receptor Hs Antagonist Antagonist 7.2 pKi - 1
pKi 7.2 [1]
5-HT1A receptor Hs Antagonist Antagonist 6.3 pKi - 1
pKi 6.3 [1]