labetuzumab govitecan   Click here for help

GtoPdb Ligand ID: 8252

Synonyms: hMN-14-SN-38 | hMN-14-SN-38 ADC | IMMU 130 | IMMU-130
Compound class: Antibody
Comment: Labetuzumab govitecan (research code IMMU-130) is an antibody-drug conjugate (ADC) in which the anti-CEACAM5 antibody labetuzumab, is covalently bound to SN-38, the active metabolite of the topoisomerase inhibitor irinotecan (as exemplified in patents [2] and [1]).
Bioactivity Comments
Conjugating the drug moeity should have little effect on the binding affinity of the antibody for its target CEACAM5.
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CD66e (CEACAM5) Primary target of this compound Hs Antibody Binding - - -
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