CCL21 
GtoPdb Ligand ID: 811
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Synonyms: ckβ9 | TCA-4
Compound class:
Endogenous peptide in human, mouse or rat
Comment: CCL21 is a CC family chemokine. It has a unique six conserved cysteine residue structure instead of the four typical of other chemokines.
Species: Human
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| Bioactivity Comments |
| CCL21 is involved in immunosurveillance. It is expressed by endothelial cells of the blood-brain barrier in physiologic and pathologic conditions and may play a role in leukocyte extravasation into the central nervous system [1]. As a result of these functions CCL21 may have potential as an immunotherapeutic agent for the treatment of gliomas. The receptor for CCL21 is CCR7. |
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