- Guide to PHARMACOLOGY
Compound class: Synthetic organic
Comment: XL388 is a highly potent, selective, ATP-competitive inhibitor of mTOR. Its discovery is described in , where it is compound 28.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|In vitro, XL388 inhibits the viability of solid and hematopoietic tumor cell lines. For example, it inhibits proliferation of MCF-7 cells with an IC50 of 1.37 μM and inhibits MCF-7 xenograft tumour growth in vivo .|
|Selectivity at enzymes|
|Key to terms and symbols||Click column headers to sort|