- Guide to PHARMACOLOGY
Compound class: Natural product or derivative
Comment: Acipidin is a natural product fungal metabolite . It inhibits cancer cell proliferation , via histone deacetylase (HDAC) inhibition.
The compound has broad-spectrum activity against apicomplexan parasites including Plasmodium species . The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Apicidin has in vitro activity against P. falciparum (strain Dd2, MIC of 125 ng/ml) and other species of apicomplexan parasite (MIC of 4-62 ng/ml) . This activity is likely to be due to potent inhibition of histone deacetylase (E. tenella histone deacetylase, IC50 of 4nM) .|
|Selectivity at enzymes|
|Key to terms and symbols||Click on species/strain names for details||Click column headers to sort|