oprelvekin

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Ligands
oprelvekin

GtoPdb Ligand ID: 6971

Synonyms: Neumega®

oprelvekin is an approved drug (FDA (1997))

Compound class: Peptide or derivative

Comment: This is a non-glycosylated, recombinant form of human IL-11 produced in E.coli. Oprelvekin is one amino acid shorter than the endogenous peptide, lacking the amino-terminal proline residue.

Summary
Biological activity
Clinical data
References
Structure
Similar ligands
Immunopharmacology

Bioactivity Comments
Recombinant human IL-11 promotes cellular proliferation of Ba/F3 cells exogenously expressing IL-11 receptors, with an EC₅₀ value of 2.5ng/mL [2], so it would be expected that oprelvekin would have similar activity.

Bioactivity Comments

Recombinant human IL-11 promotes cellular proliferation of Ba/F3 cells exogenously expressing IL-11 receptors, with an EC₅₀ value of 2.5ng/mL [2], so it would be expected that oprelvekin would have similar activity.

Selectivity at catalytic receptors

Key to terms and symbols

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Target			Sp.	Type	Action	Value	Parameter	Concentration range (M)	Reference
Interleukin-11 receptor			Hs	Agonist	Full agonist	-	-	-	1,3
⤷	[1,3]