lorazepam   Click here for help

GtoPdb Ligand ID: 5884

Synonyms: Ativan® | Orfidal®
Approved drug
lorazepam is an approved drug (FDA (1977))
Compound class: Synthetic organic
Comment: Lorazepam is used for the short-term management of severe anxiety. where it is thought to have a high affinity for GABA receptors. In March of 2016 it has also been reported as a GPR68 surrogate allosteric ligand [1].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 61.69
Molecular weight 320.01
XLogP 3.9
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES Clc1ccc2c(c1)C(=NC(C(=O)N2)O)c1ccccc1Cl
Isomeric SMILES Clc1ccc2c(c1)C(=NC(C(=O)N2)O)c1ccccc1Cl
InChI InChI=1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)
InChI Key DIWRORZWFLOCLC-UHFFFAOYSA-N
Bioactivity Comments
Due to the complex and varied nature of the precise subunit composition of GABAA receptors, and a paucity of affinity data with definitive molecular details, we have not tagged a primary target for this drug. In March 2016 lorazepam was reported as a GPR68 positive allosteric modulator for the agonist proton for cAMP production.
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
α1B-adrenoceptor Rn Allosteric modulator Positive 3.8 pKi - 2
⤷ pKi 3.8 (Ki 1.7x10-4 M) [2]
GPR68 Hs Allosteric modulator Positive - - - 1
⤷ lorazepam characterised as a non-selective GPR68 positive allosteric modulator for the agonist proton in cAMP production [1]