- Guide to PHARMACOLOGY
Compound class: Synthetic organic
Comment: The structure and activity of ruboxistaurin (as LY333531) is reported in . Ruboxistaurin is selective for the PKC isozymes PKCβI and PKCβII compared to PKCα.
This compound is proposed to have therapeutic potential for treatment of nephropathy and vascular complications associated with diabetes mellitus .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Ruboxistaurin is considered as a PKCβ selective inhibitor [4-5], although there are reports that it also inhibits Pim-1 tyrosine kinase .|
|Selectivity at enzymes|
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