rizatriptan   Click here for help

GtoPdb Ligand ID: 51

Synonyms: Maxalt® | MK-0462 | MK-462 | MK-A462 | rizatriptan benzoate
Approved drug
rizatriptan is an approved drug (FDA (1998))
Compound class: Synthetic organic
Comment: Rizatriptan is a triptan 5-HT1 receptor agonist anti-migraine drug.
Click here for help
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: rizatriptan

2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 49.74
Molecular weight 269.16
XLogP 1.47
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C
Isomeric SMILES CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C
InChI InChI=1S/C15H19N5/c1-19(2)6-5-13-8-17-15-4-3-12(7-14(13)15)9-20-11-16-10-18-20/h3-4,7-8,10-11,17H,5-6,9H2,1-2H3
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
5-HT1D receptor Primary target of this compound Hs Agonist Full agonist 7.9 pKi - 1
pKi 7.9 [1]
5-HT1B receptor Primary target of this compound Hs Agonist Partial agonist 6.9 pKi - 1
pKi 6.9 [1]
5-ht1e receptor Hs Agonist Full agonist 6.8 pKi - 1
pKi 6.8 [1]
5-HT1F receptor Hs Agonist Full agonist 6.4 – 6.8 pKi - 1-2
pKi 6.4 – 6.8 [1-2]
5-HT1A receptor Hs Agonist Full agonist 6.4 pKi - 1
pKi 6.4 [1]