IL-23

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Ligands
IL-23 (Human)

GtoPdb Ligand ID: 4978

Compound class: Endogenous peptide in human, mouse or rat

Comment: IL-23 is an IL-12 family cytokine. Structurally it is a heterodimer consisting of IL-12B and IL-23A subunits.

Species: Human

Bioactivity Comments
IL-23 binds a heterodimeric receptor comprising an IL-12RP1 subunit (shared with the IL-12 receptor) and a unique receptor subunit, IL-23R. Receptor engagement activates JAK2 and Tyk2 to stimulate STAT1, -3, 4 and -5 signalling [3]. IL-23 plays an important role in bridging the innate and adaptive arms of the immune response [2]. The rationale for targeting the IL-23/IL-17/T helper type 17 (Th17) cell axis in the search for novel therapeutics for treating autoimmune inflammatory diseases is reviewed by Tang et al. (2012) [4], and further analysis of the role of IL-12 family cytokines in infection, inflammation and autoimmune disease is provided in [1].

Bioactivity Comments

IL-23 binds a heterodimeric receptor comprising an IL-12RP1 subunit (shared with the IL-12 receptor) and a unique receptor subunit, IL-23R. Receptor engagement activates JAK2 and Tyk2 to stimulate STAT1, -3, 4 and -5 signalling [3]. IL-23 plays an important role in bridging the innate and adaptive arms of the immune response [2].
The rationale for targeting the IL-23/IL-17/T helper type 17 (Th17) cell axis in the search for novel therapeutics for treating autoimmune inflammatory diseases is reviewed by Tang et al. (2012) [4], and further analysis of the role of IL-12 family cytokines in infection, inflammation and autoimmune disease is provided in [1].

Natural/Endogenous Targets