Ligand id: 3047

Name: (R)-5-diphosphomevalonate

Structure and Physico-chemical Properties

2D Structure
Click here for structure editor
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 5
Rotatable bonds 8
Topological polar surface area 190.44
Molecular weight 308.01
XLogP -3.31
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Natural/Endogenous Targets
phosphomevalonate kinase
Enzymes Catalysing Reactions with this Compound as a Substrate or Product
Enzyme EC number Reaction Reference
diphosphomevalonate decarboxylase 3-7
phosphomevalonate kinase 1-2
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
phosphomevalonate kinase Hs Inhibitor Competitive 4.8 pKi - 2
pKi 4.8 (Ki 1.8x10-5 M) [2]
Conditions: ATP concentration constant and saturating, 42-105µM mevalonate 5-phosphate