dihydrosphingosine 1-phosphate   Click here for help

GtoPdb Ligand ID: 2921

Synonyms: dihydroS1P | sphinganine 1-phosphate | sphinganine-phosphate
Compound class: Metabolite or derivative
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 18
Topological polar surface area 122.82
Molecular weight 381.26
XLogP 5.04
No. Lipinski's rules broken 2
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCCCCCCCCCCCCCCC(C(COP(=O)(O)O)N)O
Isomeric SMILES CCCCCCCCCCCCCCC[C@H]([C@H](COP(=O)(O)O)N)O
InChI InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/t17-,18+/m0/s1
InChI Key YHEDRJPUIRMZMP-ZWKOTPCHSA-N
Natural/Endogenous Targets
Target
GPR63
S1P1 receptor
S1P2 receptor
S1P3 receptor
S1P4 receptor
S1P5 receptor
Enzymes Catalysing Reactions with this Compound as a Substrate or Product
Enzyme EC number Reaction Reference
sphingosine-1-phosphate phosphatase 1 3.1.3.- Sphingosine 1-phosphate -> sphingosine + inorganic phosphate
dihydrosphingosine 1-phosphate -> dihydrosphingosine + inorganic phosphate
5'(3')-nucleotidase 3.1.3.- Sphingosine 1-phosphate -> sphingosine + inorganic phosphate
dihydrosphingosine 1-phosphate -> dihydrosphingosine + inorganic phosphate
Mitochondrial 5'-nucleotidase 3.1.3.- Sphingosine 1-phosphate -> sphingosine + inorganic phosphate
dihydrosphingosine 1-phosphate -> dihydrosphingosine + inorganic phosphate
sphingosine-1-phosphate phosphatase 2 3.1.3.- Sphingosine 1-phosphate -> sphingosine + inorganic phosphate
dihydrosphingosine 1-phosphate -> dihydrosphingosine + inorganic phosphate
sphingosine-1-phosphate lyase 1 4.1.2.27 Sphingosine 1-phosphate -> phosphoethanolamine + hexadecenal
dihydrosphingosine 1-phosphate -> phosphoethanolamine + hexadecanal
sphingosine kinase 1 2.7.1.91 Sphingosine + ATP = sphingosine 1-phosphate + ADP
dihydrosphingosine + ATP = dihydrosphingosine 1-phosphate + ADP
sphingosine kinase 2 2.7.1.91 Sphingosine + ATP = sphingosine 1-phosphate + ADP
dihydrosphingosine + ATP = dihydrosphingosine 1-phosphate + ADP
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
GPR63 Ligand is endogenous in the given species Hs Agonist Full agonist 6.2 pEC50 - 4
⤷ pEC50 6.2 (EC50 6.8x10-7 M) [4]
S1P4 receptor Hs Agonist Agonist 8.0 pIC50 - 2
⤷ pIC50 8.0 [2]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Potency order of endogenous ligands at S1P3 receptor sphingosine 1-phosphate > dihydrosphingosine 1-phosphate 5
Potency order of endogenous ligands at S1P2 receptor sphingosine 1-phosphate > dihydrosphingosine 1-phosphate 1,5
Potency order of endogenous ligands at S1P1 receptor sphingosine 1-phosphate > dihydrosphingosine 1-phosphate 1,5
Potency order of endogenous ligands at S1P4 receptor sphingosine 1-phosphate > dihydrosphingosine 1-phosphate 6
Potency order of endogenous ligands at S1P5 receptor sphingosine 1-phosphate > dihydrosphingosine 1-phosphate 3