Synonyms: leukotriene B4
Compound class:
Metabolite
Comment: Leukotriene LTD4 is a BLT1/BLT2 receptor agonist. It induces contraction of smooth muscle, resulting in bronchoconstriction and vasoconstriction. and functions as a potent chemotactic factor.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖![]() View more information in the IUPHAR Pharmacology Education Project: ltb4 |
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Natural/Endogenous Targets | ||||
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Selectivity at GPCRs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Selectivity at ion channels | ||||||||||||||||||||||||||||||||||
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Selectivity at nuclear hormone receptors | ||||||||||||||||||||||||||||||||||
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Additional information and targets (data relate to human unless otherwise stated) | ||
Description | Data | Reference |
Potency order of endogenous ligands at BLT2 receptor | 12-hydroxyheptadecatrienoic acid > LTB4 > 12S-HETE = 12S-HPETE > 15S-HETE > 12R-HETE > 20-hydroxy-LTB4 | 9,11 |
Potency order of endogenous ligands at BLT1 receptor | LTB4 >20-hydroxy-LTB4 >>12R-HETE | 11 |
Targets where the ligand is described in the comment field | |
Target | Comment |
CYP4F3 | Responsible for ω-hydroxylation of LTB4, LXB4 [8] and polyunsaturated fatty acids [3-4], and ω-hydroxylation of fatty acid epoxides [7]. Possible role in Crohn's disease [1]. |
CYP4F2 | Responsible for ω-hydroxylation of LTB4, LXB4 [8], and tocopherols, including vitamin E [10]. Associated with the warfarin response [13]. |
Ligand mentioned in the following text fields |
1C. Peroxisome proliferator-activated receptors overview |
Leukotriene and lipoxin metabolism overview |