Ni2+   Click here for help

GtoPdb Ligand ID: 2476

Synonyms: nickel ion
Compound class: Inorganic
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
Solute carrier family 41 member 2 1
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Cav2.1 Rn Channel blocker - - - 1x10-4 - 1x10-3 8
⤷ Conc range: 1x10-4 - 1x10-3 M [8]
Voltage: -100.0 mV
TRPP1 Hs Channel blocker - - - 1x10-4 5
⤷ Conc range: 1x10-4 M [5]
Voltage: 0.0 mV
Cav3.2 Hs Channel blocker Pore blocker 4.9 – 5.2 pIC50 - 4
⤷ pIC50 4.9 – 5.2 (IC50 1.2x10-5 – 5.7x10-6 M) [4]
Voltage: -90.0 mV
Cav2.3 Hs Channel blocker Antagonist 4.6 pIC50 - 7
⤷ pIC50 4.6 (IC50 2.74x10-5 M) [7]
Voltage: -90.0 mV
Cav2.3 Rn Gating inhibitor Antagonist 3.6 – 4.7 pIC50 - 6,8
⤷ pIC50 3.6 – 4.7 [6,8]
Voltage: -100.0 mV
Cav3.3 Rn Channel blocker Antagonist 3.7 – 4.1 pIC50 - 4
⤷ pIC50 3.7 – 4.1 (IC50 2.16x10-4 – 8.7x10-5 M) [4]
Voltage: -90.0 mV
Cav3.1 Rn Channel blocker Antagonist 3.6 – 3.8 pIC50 - 4
⤷ pIC50 3.6 – 3.8 (IC50 2.5x10-4 – 1.67x10-4 M) [4]
Voltage: -90.0 mV
CatSper1 Mm Channel blocker Inhibition 3.5 pIC50 - 3
⤷ pIC50 3.5 (IC50 3x10-4 M) [3]
Description: Whole cell patch clamp
CatSper2 Mm Channel blocker Antagonist 3.5 pIC50 - 2
⤷ pIC50 3.5 (IC50 3x10-4 M) [2]
Description: Whole cell patch clamp.
CatSper3 Mm Channel blocker Antagonist 3.5 pIC50 - 3
⤷ pIC50 3.5 (IC50 3x10-4 M) [3]
Description: Whole cell patch clamp electrophysiology.
CatSper4 Mm Channel blocker Antagonist 3.5 pIC50 - 3
⤷ pIC50 3.5 (IC50 3x10-4 M) [3]
Description: Whole cell patch clamp electrophysiology.
TRPC3 Hs Channel blocker - - - -
⤷