PHI   Click here for help

GtoPdb Ligand ID: 2273

Synonyms: peptide histidine-isoleucine
Compound class: Peptide or derivative
Comment: The porcine sequence has been used in pharmacological studies. Sequences in mouse and rat have isoleucine in place of leucine at position 17. The human sequence (PHM) has C-terminal methionine.
Species: Pig
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
VPAC1 receptor Rn Agonist Agonist 8.5 pIC50 - 1
⤷ pIC50 8.5 (IC50 3x10-9 M) [1]
Description: inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
VPAC2 receptor Hs Agonist Agonist 7.5 pIC50 - 1
⤷ pIC50 7.5 (IC50 3x10-8 M) [1]
Description: inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor
VPAC2 receptor Rn Agonist Agonist 7.5 pIC50 - 1
⤷ pIC50 7.5 (IC50 3x10-8 M) [1]
Description: inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor
VPAC1 receptor Hs Agonist Agonist 6.0 pIC50 - 1
⤷ pIC50 6.0 (IC50 1x10-6 M) [1]
Description: inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Potency order of endogenous ligands at VPAC2 receptor VIP (VIP, P01282), PACAP-38 (ADCYAP1, P18509), PACAP-27 (ADCYAP1, P18509) > PHI >> GHRH (GHRH, P01286), secretin (SCT, P09683)
Potency order of endogenous ligands at VPAC1 receptor VIP (VIP, P01282), PACAP-27 (ADCYAP1, P18509), PACAP-38 (ADCYAP1, P18509) >> GHRH (GHRH, P01286), PHI, secretin (SCT, P09683)