PHI   

GtoPdb Ligand ID: 2273

Synonyms: peptide histidine-isoleucine
Comment: The porcine sequence has been used in pharmacological studies. Sequences in mouse and rat have isoleucine in place of leucine at position 17. The human sequence (PHM) has C-terminal methionine.
Species: Pig
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
VPAC1 receptor Rn Agonist Agonist 8.5 pIC50 - 1
pIC50 8.5 (IC50 3x10-9 M) [1]
Description: inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
VPAC2 receptor Hs Agonist Agonist 7.5 pIC50 - 1
pIC50 7.5 (IC50 3x10-8 M) [1]
Description: inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor
VPAC2 receptor Rn Agonist Agonist 7.5 pIC50 - 1
pIC50 7.5 (IC50 3x10-8 M) [1]
Description: inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor
VPAC1 receptor Hs Agonist Agonist 6.0 pIC50 - 1
pIC50 6.0 (IC50 1x10-6 M) [1]
Description: inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference