tozorakimab   Click here for help

GtoPdb Ligand ID: 12964

Synonyms: MEDI-3506 | MEDI3506
Immunopharmacology Ligand
Compound class: Antibody
Comment: Tozorakimab (MEDI3506) is a high-affinity anti-IL-33 monoclonal antibody. It inhibits IL-33-induced signalling to produce an anti-inflammatory effect [2]. Tozorakimab blocks the actions of both reduced IL-33 (IL-33red) and oxidized IL-33 (IL-33ox) metabolites through their respective downstream pathways (ST2 for IL-33red, RAGE/EGFR complex for IL-33ox) [1,3-4].
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
IL-33 Hs Antibody Binding 10.1 pIC50 - 2
⤷ pIC50 10.1 (IC50 8.2x10-11 M) [2]
Description: Potency for binding between antibody and IL33red.