Synonyms: Compound S-D1 [WO2021155225A1] | FHD609
Compound class:
Synthetic organic
Comment: FHD-609 is a PROTAC degrader of bromodomain-containing protein 9 (BRD9), that was designed as a treatment for synovial sarcoma and SMARCB1-loss tumours. It is one of the compounds claimed in Foghorn Therapeutics' patent WO2021155225A1 [1]. FHD-609 is suitable for intravenous delivery.
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Bioactivity Comments |
In a cell-based degradation assay, the parent (racemic) version of FHD-609 degrades BRD9 with an IC50 of 0.13 nM [1]. |