- Guide to PHARMACOLOGY
Compound class: Synthetic organic
Comment: JX21108 is a selective inhibitor of P. falciparum histone deacetylase 1 (PfHDAC1) that was developed from chemical optimization of quisinostat .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|JX21108 demonstrates activity against multiple Plasmodium lifecycle stages. The interaction table below provides data from whole cell assays and gives the antiparasite activity of JX21108 against both the sexual and asexual blood stages. In addition, no sign of liver infection was observed in a P. berghei mouse model using a single 60 mg/kg dose .
|Whole organism assay data
|Key to terms and symbols
|Click on species/strain names for details
|Click column headers to sort