Synonyms: BMS986299 | compound 112 [WO2018152396A1]
Compound class:
Synthetic organic
Comment: BMS-986299 is a NLRP3 inflammasome modulator (agonist) [1]. It induces production of IL-1β and IL-8 and it is being examined for immunomodulatory and antineoplastic activities. Enhanced IL-8 is predicted to induce tumouricidal activity of natural killer (NK) cells against cancer cells.
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Bioactivity Comments |
BMS-986299 increases IL-1β production in vitro (EC50 1280 nM), and exhibits in vivo anti-tumour efficacy in preclinical syngeneic tumour models [1]. Does not bind to TLR7 or TLR8. |