litifilimab   Click here for help

GtoPdb Ligand ID: 11122

Synonyms: BIIB-059 | BIIB059
Immunopharmacology Ligand
Compound class: Antibody
Comment: Litifilimab (BIIB059) is a fully humanized IgG1, CLEC4C (blood dendritic cell antigen 2, BDCA2) targeting monoclonal antibody. It is being evaluated for ability to reduce release of disease-driving interferons (principally IFN-α) in SLE/CLE. BIIB059 was developed by Biogen, based on prior evidence of target engagement and SLE-applicable immunomodulatory efficacy of a humanized mAb against BDCA2 named 24F4A [3].
Selectivity at other protein targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
C-type lectin domain family 4 member C Hs Antibody Binding - - - 1