indoximod   Click here for help

GtoPdb Ligand ID: 8226

Synonyms: 1-methyl-D-tryptophan | 1MT | D-1MT
Compound class: Synthetic organic
Comment: Indoximod is being investigated for its inhibitory action towards indoleamine 2,3-dioxygenase 1 (IDO1), a L-tryptophan degrading enzyme.

indoximod is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 68.25
Molecular weight 218.11
XLogP -0.97
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES OC(=O)C(Cc1cn(c2c1cccc2)C)N
Isomeric SMILES OC(=O)[C@@H](Cc1cn(c2c1cccc2)C)N
InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m1/s1
InChI Key ZADWXFSZEAPBJS-SNVBAGLBSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Similar Ligands Click here for help
1-methyl-L-tryptophan
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Targets
indoleamine 2,3-dioxygenase 1
D-tryptophan
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HCA3 receptor
6-fluorotryptophan
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L-Tryptophan hydroxylase 1; L-Tryptophan hydroxylase 2
1-methyltryptophan
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ATB0,+
α-methyl-D,L-tryptophan
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ATB0,+; Proton-coupled Amino acid Transporter 2
5-hydroxy-L-tryptophan
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L-Aromatic amino-acid decarboxylase ; Proton-coupled Amino acid Transporter 1; Proton-coupled Amino acid Transporter 2
L-tryptophan
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Targets
GPR139; ATB0,+; CaS receptor; L-Aromatic amino-acid decarboxylase ; L-Tryptophan hydroxylase 1; L-Tryptophan hydroxylase 2; Monocarboxylate transporter 10; Proton-coupled Amino acid Transporter 1; Proton-coupled Amino acid Transporter 4