nepafenac   Click here for help

GtoPdb Ligand ID: 7564

Synonyms: AHR-9434 | AL-6515 | Nevanac®
Approved drug
nepafenac is an approved drug (FDA (2005), EMA (2007))
Compound class: Synthetic organic
Comment: Nepafenac is a non-steroidal anti-inflammatory drug (NSAID).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 86.18
Molecular weight 254.11
XLogP 1.89
No. Lipinski's rules broken 0
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Canonical SMILES NC(=O)Cc1cccc(c1N)C(=O)c1ccccc1
Isomeric SMILES NC(=O)Cc1cccc(c1N)C(=O)c1ccccc1
InChI InChI=1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18)
Classification Click here for help
Compound class Synthetic organic
Ligand families/groups Non-steroidal anti-inflammatory ligands
Approved drug? Yes (FDA (2005), EMA (2007))
Is prodrug? Yes
Active form amfenac
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
7685 nepafenac
Synonyms Click here for help
AHR-9434 | AL-6515 | Nevanac®
Database Links Click here for help
CAS Registry No. 78281-72-8
ChEMBL Ligand CHEMBL1021
DrugBank Ligand DB06802
DrugCentral Ligand 1899, 1899
GtoPdb PubChem SID 223365900
PubChem CID 151075
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Wikipedia Nepafenac