nepafenac   Click here for help

GtoPdb Ligand ID: 7564

Synonyms: AHR-9434 | AL-6515 | Nevanac®
Approved drug
nepafenac is an approved drug (FDA (2005), EMA (2007))
Compound class: Synthetic organic
Comment: Nepafenac is a non-steroidal anti-inflammatory drug (NSAID).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 86.18
Molecular weight 254.11
XLogP 1.89
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES NC(=O)Cc1cccc(c1N)C(=O)c1ccccc1
Isomeric SMILES NC(=O)Cc1cccc(c1N)C(=O)c1ccccc1
InChI InChI=1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18)
InChI Key QEFAQIPZVLVERP-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Ligand families/groups Non-steroidal anti-inflammatory ligands
Approved drug? Yes (FDA (2005), EMA (2007))
Is prodrug? Yes
Active form amfenac
IUPAC Name Click here for help
2-[2-amino-3-(benzoyl)phenyl]acetamide
International Nonproprietary Names Click here for help
INN number INN
7685 nepafenac
Synonyms Click here for help
AHR-9434 | AL-6515 | Nevanac®
Database Links Click here for help
CAS Registry No. 78281-72-8
ChEBI CHEBI:75922
ChEMBL Ligand CHEMBL1021
DrugBank Ligand DB06802
DrugCentral Ligand 1899
GtoPdb PubChem SID 223365900
PubChem CID 151075
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Wikipedia Nepafenac