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oprelvekin   Click here for help

GtoPdb Ligand ID: 6971

Synonyms: Neumega®
Approved drug Immunopharmacology Ligand
oprelvekin is an approved drug (FDA (1997))
Compound class: Peptide
Comment: This is a non-glycosylated, recombinant form of human IL-11 produced in E.coli. Oprelvekin is one amino acid shorter than the endogenous peptide, lacking the amino-terminal proline residue.
Bioactivity Comments
Recombinant human IL-11 promotes cellular proliferation of Ba/F3 cells exogenously expressing IL-11 receptors, with an EC50 value of 2.5ng/mL [2], so it would be expected that oprelvekin would have similar activity.
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target
Sp.
Type
Action
Reference
Interleukin-11 receptor Primary target of this compound Hs Agonist Full agonist - - - 1,3
⤷ [1,3]