irbesartan   Click here for help

GtoPdb Ligand ID: 589

Synonyms: Aprovel® | Avapro® | Karvea® | SR 47436
Approved drug
irbesartan is an approved drug (EMA & FDA (1997))
Compound class: Synthetic organic
Comment: Irbesartan is an angiotensin receptor antagonist.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: irbesartan

irbesartan is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 87.13
Molecular weight 428.23
XLogP 6.06
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2
Isomeric SMILES CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2
InChI InChI=1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30)
InChI Key YOSHYTLCDANDAN-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (EMA & FDA (1997))
IUPAC Name Click here for help
2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
International Nonproprietary Names Click here for help
INN number INN
7229 irbesartan
Synonyms Click here for help
Aprovel® | Avapro® | Karvea® | SR 47436
Database Links Click here for help
Specialist databases
GPCRdb Ligand irbesartan
Reactome Drug Reactome logo R-ALL-9615287
Reactome Reaction Reactome logo R-HSA-9615249
Other databases
BindingDB Ligand 50042235
CAS Registry No. 138402-11-6
ChEBI CHEBI:5959
ChEMBL Ligand CHEMBL1513
DrugBank Ligand DB01029
DrugCentral Ligand 1481
GtoPdb PubChem SID 135650414
PubChem CID 3749
Search Google for chemical match using the InChIKey YOSHYTLCDANDAN-UHFFFAOYSA-N
Search Google for chemicals with the same backbone YOSHYTLCDANDAN
Search PubMed clinical trials irbesartan
Search PubMed titles irbesartan
Search PubMed titles/abstracts irbesartan
UniChem Compound Search for chemical match using the InChIKey YOSHYTLCDANDAN-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey YOSHYTLCDANDAN-UHFFFAOYSA-N
Wikipedia Irbesartan

Product suppliers

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Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.

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Tocris
Irbesartan (links to external site)
Cat. No. 5798