ChEMBL ligand: CHEMBL1513 (Aprovel, Avapro, BMS-186295, Ifirmasta, Irbesartan, Irbesartan bms, Irbesartan teva, Irbesartan zentiva, Karvea, NSC-758696, Sabervel, Sarbevel, SR 47436, SR-47436)
Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Human [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973] There should be some charts here, you may need to enable JavaScript!
ETA receptor/Endothelin receptor ET-A in Human [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101] There should be some charts here, you may need to enable JavaScript!
BLT2 receptor/Leukotriene B4 receptor 2 in Human [ChEMBL: CHEMBL3191] [GtoPdb: 268] [UniProtKB: Q9NPC1] There should be some charts here, you may need to enable JavaScript!
AT1 receptor in Human [GtoPdb: 34] [UniProtKB: P30556] AT1 receptor/Type-1A angiotensin II receptor in Rat [ChEMBL: CHEMBL329] [GtoPdb: 34] [UniProtKB: P25095] There should be some charts here, you may need to enable JavaScript!
AT1 receptor/Type-1 angiotensin II receptor in Human [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556] There should be some charts here, you may need to enable JavaScript!
AT1 receptor in Human [GtoPdb: 34] [UniProtKB: P30556] AT1 receptor/Type-1B angiotensin II receptor in Rat [ChEMBL: CHEMBL263] [GtoPdb: 34] [UniProtKB: P29089] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973]
GtoPdb	-	-	4.92	pKi	11900	nM	Ki	Mol Pharm (2013) 10: 1008-19 [PMID:23339484]
ChEMBL	Binding affinity to NTCP (unknown origin)	B	4.92	pKi	11900	nM	Ki	J Med Chem (2022) 65: 12546-12561 [PMID:36111355]
ChEMBL	Inhibition of NTCP (unknown origin)	B	4.52	pIC50	30000	nM	IC50	Bioorg Med Chem Lett (2019) 29: 126623-126623 [PMID:31439379]
ETA receptor/Endothelin receptor ET-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101]
ChEMBL	Inhibitory concentration against endothelin receptor type A	B	5	pKi	>10000	nM	Ki	J Med Chem (2005) 48: 6523-6543 [PMID:16220969]
ChEMBL	Binding affinity to ETA receptor	B	5	pKi	10000	nM	Ki	J Med Chem (2012) 55: 9363-9392 [PMID:22931505]
BLT2 receptor/Leukotriene B4 receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3191] [GtoPdb: 268] [UniProtKB: Q9NPC1]
ChEMBL	Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay	F	6.39	pEC50	410	nM	EC50	ACS Med Chem Lett (2021) 12: 1261-1266 [PMID:34413955]
AT1 receptor in Human [GtoPdb: 34] [UniProtKB: P30556]
GtoPdb	-	-	8.8	pIC50	1.58	nM	IC50	Br J Pharmacol (1999) 126: 1057-65 [PMID:10193788]
AT1 receptor/Type-1A angiotensin II receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL329] [GtoPdb: 34] [UniProtKB: P25095]
ChEMBL	Displacement of [125I]- Ang II from type 1 Angiotensin II receptor	B	9.05	pIC50	0.9	nM	IC50	Bioorg Med Chem Lett (1994) 4: 1527-1530
AT1 receptor/Type-1 angiotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556]
ChEMBL	In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5	B	8.7	pKi	2	nM	Ki	J Med Chem (2002) 45: 4794-4798 [PMID:12361407]
ChEMBL	Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5	B	8.7	pKi	2	nM	Ki	J Med Chem (2000) 43: 2685-2697 [PMID:10893306]
ChEMBL	Compound was evaluated for its binding affinity towards human Angiotensin II receptor, type 1	B	8.96	pKi	1.1	nM	Ki	J Med Chem (2002) 45: 3829-3835 [PMID:12190306]
ChEMBL	Inhibitory concentration against angiotensin II receptor, type 1	B	9.1	pKi	0.8	nM	Ki	J Med Chem (2005) 48: 6523-6543 [PMID:16220969]
ChEMBL	Binding affinity to AT1 receptor	B	9.1	pKi	0.8	nM	Ki	J Med Chem (2012) 55: 9363-9392 [PMID:22931505]
ChEMBL	Binding affinity to angiotensin AT1 receptor	B	7.68	pIC50	20.8	nM	IC50	Bioorg Med Chem (2010) 18: 8418-8456 [PMID:21071232]
ChEMBL	Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay	F	8.22	pIC50	6	nM	IC50	ACS Med Chem Lett (2021) 12: 1261-1266 [PMID:34413955]
GtoPdb	-	-	8.8	pIC50	1.58	nM	IC50	Br J Pharmacol (1999) 126: 1057-65 [PMID:10193788]
AT1 receptor in Human [GtoPdb: 34] [UniProtKB: P30556]
GtoPdb	-	-	8.8	pIC50	1.58	nM	IC50	Br J Pharmacol (1999) 126: 1057-65 [PMID:10193788]
AT1 receptor/Type-1B angiotensin II receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL263] [GtoPdb: 34] [UniProtKB: P29089]
ChEMBL	Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1	B	9.1	pKi	0.8	nM	Ki	J Med Chem (2002) 45: 3829-3835 [PMID:12190306]
ChEMBL	Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane	B	8.89	pIC50	1.3	nM	IC50	J Med Chem (1993) 36: 3371-3380 [PMID:8230127]
ChEMBL	In vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membrane	B	8.89	pIC50	1.3	nM	IC50	Bioorg Med Chem Lett (1994) 4: 157-162

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]