lymphotoxin-α

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Ligands
lymphotoxin-α (Human)

GtoPdb Ligand ID: 5064

Abbreviated name: TNFSF1

Synonyms: LTα | TNFβ

Compound class: Endogenous peptide in human, mouse or rat

Comment: LTA (TNFβ) is a pro-inflammarory cytokine mediating a large variety of inflammatory, immunostimulatory, and antiviral responses. LTA is required during embryonic development of lymphoid organs.

Species: Human

Summary
Biological activity
References
Structure
Similar ligands
Immunopharmacology

Is a component of
lymphotoxin β₂α₁ heterotrimer

Is a component of

lymphotoxin β₂α₁ heterotrimer

Peptide Sequence
LPGVGLTPSAAQTARQHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVV FSGKAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHLVLS PSTVFFGAFAL

Selected 3D Structures

PDB Id: 1tnr

Image of ligand 3D structure from RCSB PDB

Post-translational Modification
Partial O-linked glycosylation of threonine residue at position 7; N-linked glycosylation of asparagine at position 62