lymphotoxin-α   Click here for help

GtoPdb Ligand ID: 5064

Abbreviated name: TNFSF1
Synonyms: LTα | TNFβ
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: LTA (TNFβ) is a pro-inflammarory cytokine mediating a large variety of inflammatory, immunostimulatory, and antiviral responses. LTA is required during embryonic development of lymphoid organs.
Species: Human
Natural/Endogenous Targets
Target
herpes virus entry mediator
toxicity and JNK inducer
tumor necrosis factor receptor 1
tumor necrosis factor receptor 2
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
tumor necrosis factor receptor 1 Ligand is endogenous in the given species Hs None - - - -
⤷
tumor necrosis factor receptor 2 Ligand is endogenous in the given species Hs None - - - -
⤷
herpes virus entry mediator Ligand is endogenous in the given species Hs None - - - -
⤷
toxicity and JNK inducer Ligand is endogenous in the given species N/A None - - - -
⤷
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
pateclizumab Peptide Primary target of this compound Hs Antibody Binding 10.3 pEC50 - 1
⤷ pEC50 10.3 (EC50 5x10-11 M) [1]
Description: Binding to the LTα trimer LTα3