L-tyrosine   Click here for help

GtoPdb Ligand ID: 4791

Abbreviated name: L-Tyr
PDB Ligand
Compound class: Metabolite
Comment: Tyrosine is precursor to noradenaline.

L-tyrosine is commercially available from our sponsors

2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 3
Topological polar surface area 83.55
Molecular weight 181.07
XLogP -1.78
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

✖
Canonical SMILES OC(=O)C(Cc1ccc(cc1)O)N
Isomeric SMILES OC(=O)[C@H](Cc1ccc(cc1)O)N
InChI InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1
InChI Key OUYCCCASQSFEME-QMMMGPOBSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Enzymes Catalysing Reactions with this Compound as a Substrate or Product
Enzyme EC number Reaction Reference
L-Tyrosine hydroxylase 1.14.16.2 L-tyrosine + O2 -> levodopa
L-Phenylalanine hydroxylase 1.14.16.1 L-phenylalanine + O2 -> L-tyrosine
Tyrosine aminotransferase 2.6.1.5 L-tyrosine + α-ketoglutaric acid -> 4-hydroxyphenylpyruvic acid + L-glutamic acid
iodotyrosine deiodinase 1.22.1.1 3-Iodotyrosine -> L-tyrosine + I-
3,5-diiodo-L-tyrosine -> 3-iodotyrosine + I-
Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
Monocarboxylate transporter 10
sodium-coupled neutral amino acid transporter 1 1
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Substrates at sodium-coupled neutral amino acid transporter 1 L-alanine > L-serine, L-glutamine, L-asparagine, L-histidine, L-cysteine, L-methionine > glycine, L-threonine, L-proline, L-tyrosine, L-valine 1
Ligand mentioned in the following text fields
Catecholamine turnover overview