System A-like transporters | Transporters | IUPHAR/BPS Guide to MALARIA PHARMACOLOGY

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Targets
Transporters
SLC superfamily of solute carriers
SLC38 family of sodium-dependent neutral amino acid transporters
System A-like transporters

System A-like transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Transporters

1169

SNAT1 (sodium-coupled neutral amino acid transporter 1 / SLC38A1) C Show summary »« Hide summary

Target Id

1169

Nomenclature

sodium-coupled neutral amino acid transporter 1

Systematic nomenclature

SLC38A1

Common abbreviation

SNAT1

Previous and unofficial names

Genes

SLC38A1 (Hs), Slc38a1 (Mm), Slc38a1 (Rn)

Ensembl ID

ENSG00000111371 (Hs), ENSMUSG00000023169 (Mm), ENSRNOG00000005291 (Rn)

UniProtKB AC

Q9H2H9 (Hs), Q8K2P7 (Mm), Q9JM15 (Rn)

Bioparadigms SLC Tables

SLC38A1 (Hs)

RESOLUTE

SLC38A1 (Hs)

Substrates

L-alanine > L-serine, L-glutamine, L-asparagine, L-histidine, L-cysteine, L-methionine > glycine, L-threonine, L-proline, L-tyrosine, L-valine [1]

Substrates

MeAIB

Labelled ligands

[¹⁴C]alanine

[³H]alanine

Stoichiometry

1 Na⁺ : 1 amino acid (in) [1]

SNAT2 (sodium-coupled neutral amino acid transporter 2 / SLC38A2) C Show summary »« Hide summary

SNAT4 (sodium-coupled neutral amino acid transporter 4 / SLC38A4) C Show summary »« Hide summary

References

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1. Albers A, Bröer A, Wagner CA, Setiawan I, Lang PA, Kranz EU, Lang F, Bröer S. (2001) Na+ transport by the neural glutamine transporter ATA1. Pflugers Arch, 443 (1): 92-101. [PMID:11692272]

2. Hatanaka T, Huang W, Ling R, Prasad PD, Sugawara M, Leibach FH, Ganapathy V. (2001) Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A. Biochim Biophys Acta, 1510 (1-2): 10-7. [PMID:11342143]

3. Hatanaka T, Huang W, Wang H, Sugawara M, Prasad PD, Leibach FH, Ganapathy V. (2000) Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A. Biochim Biophys Acta, 1467 (1): 1-6. [PMID:10930503]

How to cite this family page

Database page citation:

System A-like transporters. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=225.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.