L-methionine   Click here for help

GtoPdb Ligand ID: 4814

Abbreviated name: L-Met
PDB Ligand
Compound class: Metabolite

L-methionine is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 88.62
Molecular weight 149.05
XLogP -1.85
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CSCCC(C(=O)O)N
Isomeric SMILES CSCC[C@@H](C(=O)O)N
InChI InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChI Key FFEARJCKVFRZRR-BYPYZUCNSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Metabolite
IUPAC Name Click here for help
(2S)-2-amino-4-(methylsulfanyl)butanoic acid
International Nonproprietary Names Click here for help
INN number INN
452 methionine
Database Links Click here for help
CAS Registry No. 63-68-3 (source: Scifinder)
ChEBI CHEBI:16643
ChEMBL Ligand CHEMBL42336
DrugBank Ligand DB00134
DrugCentral Ligand 3347
GtoPdb PubChem SID 178101516
PubChem CID 6137
RCSB PDB Ligand MET
Search Google for chemical match using the InChIKey FFEARJCKVFRZRR-BYPYZUCNSA-N
Search Google for chemicals with the same backbone FFEARJCKVFRZRR
Search PubMed clinical trials methionine
Search PubMed titles methionine
Search PubMed titles/abstracts methionine
UniChem Compound Search for chemical match using the InChIKey FFEARJCKVFRZRR-BYPYZUCNSA-N
UniChem Connectivity Search for chemical match using the InChIKey FFEARJCKVFRZRR-BYPYZUCNSA-N

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MedChemExpress
L-Methionine (links to external site)
Cat. No. HY-N0326