- Guide to PHARMACOLOGY
Synonyms: Glucophage® | LA-6023
metformin is an approved drug (FDA (1995))
Compound class: Synthetic organic
Comment: Marketed formulations contain metformin hydrochloride (PubChem CID 14219). Metformin is often given in fixed-dose combinations with other antihyperglycemic agents.
Repurposing: Cancer cells undergo a metabolic switch to aerobic glycolysis, and become reliant on this metabolic pathway for energy (the Warburg effect). Inhibition of the glycolytic pathway is therefore considered as a tractable therapeutic target in oncology. As metformin is an inhibitor of glycolysis it is being examined for anti-cancer effects in a number of malignancies. Similarly, it is being examined for anti-inflammatory potential since activated immune cells also undergo a metabolic switch to aerobic glycolysis. If found to be effective, this could ultimately lead to metformin being repurposed for indications other than type 2 diabetes.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: metformin
|Compound class||Synthetic organic|
|Approved drug?||Yes (FDA (1995))|
|WHO Essential Medicine||WHO Essential Medicines List (EML) (22nd List, 2021). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
|International Nonproprietary Names|
|Glucophage® | LA-6023|
|CAS Registry No.||657-24-9|
|GtoPdb PubChem SID||178101481|
|RCSB PDB Ligand||MF8|
|Search Google for chemical match using the InChIKey||XZWYZXLIPXDOLR-UHFFFAOYSA-N|
|Search Google for chemicals with the same backbone||XZWYZXLIPXDOLR|
|Search PubMed clinical trials||metformin|
|Search PubMed titles||metformin|
|Search PubMed titles/abstracts||metformin|
|UniChem Compound Search for chemical match using the InChIKey||XZWYZXLIPXDOLR-UHFFFAOYSA-N|
|UniChem Connectivity Search for chemical match using the InChIKey||XZWYZXLIPXDOLR-UHFFFAOYSA-N|