GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

GDP-fucose   Click here for help

GtoPdb Ligand ID: 4578

Synonyms: GDP-L-fucose | guanosine diphosphate fucose
Compound class: Metabolite
2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 18
Hydrogen bond donors 9
Rotatable bonds 8
Topological polar surface area 331.11
Molecular weight 589.08
XLogP -3.45
No. Lipinski's rules broken 2

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

✖
Canonical SMILES OC1C(COP(=O)(OP(=O)(OC2OC(C)C(C(C2O)O)O)O)O)OC(C1O)n1cnc2c1[nH]c(N)nc2=O
Isomeric SMILES O[C@@H]1[C@@H](COP(=O)(OP(=O)(OC2O[C@@H](C)[C@H]([C@H]([C@@H]2O)O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1[nH]c(N)nc2=O
InChI InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1
InChI Key LQEBEXMHBLQMDB-QIXZNPMTSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

For advanced searching click here to open chemical structure editor

Similar Ligands Click here for help
α,β-difluoromethylene-UDP
Click here for ligand page
Targets
P2Y14 receptor
fomivirsen
Click here for ligand page
tunicamycin
Click here for ligand page
cyclic di-GMP
Click here for ligand page
Targets
stimulator of interferon response cGAMP interactor 1
FUZS-5
Click here for ligand page
LIZA-7
Click here for ligand page
compound 27 [WO2019226977A1]
Click here for ligand page
Targets
TLR7
Rp-8-Br-cGMPS
Click here for ligand page
Targets
null
agatolimod
Click here for ligand page
Targets
TLR9
trifluridine
Click here for ligand page
nelarabine
Click here for ligand page
cyclic CMP
Click here for ligand page
Targets
HCN2
α.β-methylene-2-thio-UDP
Click here for ligand page
Targets
P2Y14 receptor
2-thio-UDP
Click here for ligand page
Targets
P2Y14 receptor
N4-phenylethoxycytidine-5'-triphosphate
Click here for ligand page
Targets
P2Y4 receptor
MRS2927
Click here for ligand page
Targets
P2Y4 receptor
MRS2802
Click here for ligand page
Targets
P2Y14 receptor
MRS2905
Click here for ligand page
Targets
P2Y14 receptor
MRS2957
Click here for ligand page
Targets
P2Y6 receptor
PSB1114
Click here for ligand page
Targets
P2Y2 receptor
TTP
Click here for ligand page
GDPβS
Click here for ligand page
5'-UMP
Click here for ligand page
Targets
Ecto-5'-Nucleotidase
5'-inosine monophosphate
Click here for ligand page
Targets
Ecto-5'-Nucleotidase
5'-GMP
Click here for ligand page
Targets
Ecto-5'-Nucleotidase
5'-dGMP
Click here for ligand page
Targets
Ecto-5'-Nucleotidase
2'-deoxyinosine
Click here for ligand page
poly(I:C)
Click here for ligand page
Targets
TLR3
loxoribine
Click here for ligand page
Targets
TLR7
didanosine
Click here for ligand page
Targets
Equilibrative nucleoside transporter 1; Equilibrative nucleoside transporter 3; Sodium/nucleoside cotransporter 2; Solute carrier family 28 member 3
zidovudine
Click here for ligand page
Targets
Equilibrative nucleoside transporter 2; Equilibrative nucleoside transporter 3; Sodium/nucleoside cotransporter 1; Solute carrier family 28 member 3
pentostatin
Click here for ligand page
Targets
Adenosine deaminase; Equilibrative nucleoside transporter 1
floxuridine
Click here for ligand page
Targets
Equilibrative nucleoside transporter 1; Equilibrative nucleoside transporter 3; Solute carrier family 28 member 3
UDP-N-acetylgalactosamine
Click here for ligand page
Targets
HFRC1; UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter
UDP-xylose
Click here for ligand page
Targets
YEA
thymidine
Click here for ligand page
Targets
Equilibrative nucleoside transporter 1; Equilibrative nucleoside transporter 2; Equilibrative nucleoside transporter 3; Sodium/nucleoside cotransporter 1; Sodium/nucleoside cotransporter 2; Solute carrier family 28 member 3
5-fluorouridine
Click here for ligand page
Targets
Solute carrier family 28 member 3
uridine
Click here for ligand page
Targets
Equilibrative nucleoside transporter 1; Equilibrative nucleoside transporter 2; Equilibrative nucleoside transporter 3; Sodium-dependent nucleobase transporter; Sodium/nucleoside cotransporter 1; Solute carrier family 28 member 3
inosine
Click here for ligand page
Targets
Equilibrative nucleoside transporter 1; Equilibrative nucleoside transporter 2; Equilibrative nucleoside transporter 3; Sodium/nucleoside cotransporter 2; Solute carrier family 28 member 3
GTPγS
Click here for ligand page
Targets
Maxi Cl-; VRAC
MRS4062
Click here for ligand page
Targets
P2Y4 receptor
MRS2768
Click here for ligand page
Targets
P2Y2 receptor
2-thioUTP
Click here for ligand page
Targets
P2Y2 receptor
MRS2690
Click here for ligand page
Targets
P2Y14 receptor
cADPR
Click here for ligand page
Targets
TRPM2
guanosine 5'-diphosphate
Click here for ligand page
Targets
Kir6.1; Vesicular nucleotide transporter
cyclic GMP
Click here for ligand page
Targets
CNGA1; CNGA2; CNGA3; HCN1; HCN2; phosphodiesterase 10A; phosphodiesterase 2A; phosphodiesterase 3A; phosphodiesterase 3B; phosphodiesterase 4A; phosphodiesterase 4B; phosphodiesterase 4C; phosphodiesterase 4D; phosphodiesterase 5A; phosphodiesterase 9A... click on ligand to see complete list
UDP-glucuronic acid
Click here for ligand page
Targets
P2Y14 receptor; UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter
UDP-glucose
Click here for ligand page
Targets
GPR17; P2Y14 receptor
UDP-galactose
Click here for ligand page
Targets
GPR17; P2Y14 receptor; UDP-galactose transporter
UDP N-acetyl-glucosamine
Click here for ligand page
Targets
P2Y14 receptor; UDP-N-acetylglucosamine transporter; UDP-galactose transporter; YEA
Up3U
Click here for ligand page
Targets
P2Y6 receptor
UDP-β-S
Click here for ligand page
Targets
P2Y6 receptor
UDP
Click here for ligand page
Targets
GPR17; Kir6.1; P2Y14 receptor; P2Y6 receptor
MRS2782
Click here for ligand page
Targets
P2Y6 receptor
MRS2693
Click here for ligand page
Targets
P2Y6 receptor
INS48823
Click here for ligand page
Targets
P2Y6 receptor
3-phenacyl-UDP
Click here for ligand page
Targets
P2Y6 receptor
ITP
Click here for ligand page
Targets
P2Y4 receptor
guanosine-5'-triphosphate
Click here for ligand page
Targets
Kir6.1; P2Y4 receptor; Vesicular nucleotide transporter
CTP
Click here for ligand page
Targets
P2Y4 receptor
(N)methanocarba-UTP
Click here for ligand page
Targets
P2Y4 receptor
denufosol
Click here for ligand page
Targets
P2Y2 receptor; P2Y4 receptor
diquafosol
Click here for ligand page
Targets
P2Y2 receptor; P2Y4 receptor
UTPγS
Click here for ligand page
Targets
P2Y2 receptor; P2Y4 receptor
UTP
Click here for ligand page
Targets
P2Y11 receptor; P2Y2 receptor; P2Y4 receptor; P2Y6 receptor
MRS2698
Click here for ligand page
Targets
P2Y2 receptor
5BrUTP
Click here for ligand page
Targets
P2Y2 receptor; P2Y6 receptor
4-thio-UTP
Click here for ligand page
Targets
P2Y2 receptor