glycoprotein hormone common alpha subunit

From August 18th 2026, GtoPdb will require users to register to use the website. Please see our blog post for more information.

Home
Ligands
glycoprotein hormone common alpha subunit (Human)

GtoPdb Ligand ID: 3731

Compound class: Endogenous peptide in human, mouse or rat

Species: Human

Is a component of
FSH
LH
TSH
hCG

Is a component of

FSH

TSH

hCG

Peptide Sequence
APDVQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCCVAKSYNRVTVMGGFKVENHT ACHCSTCYYHKS
Ala-Pro-Asp-Val-Gln-Asp-Cys-Pro-Glu-Cys-Thr-Leu-Gln-Glu-Asn-Pro-Phe-Phe-Ser-Gln-Pro-Gly-Ala-Pro-Ile-Leu-Gln-Cys-Met-Gly-Cys-Cys-Phe-Ser-Arg-Ala-Tyr-Pro-Thr-Pro-Leu-Arg-Ser-Lys-Lys-Thr-Met-Leu-Val-Gln-Lys-Asn-Val-Thr-Ser-Glu-Ser-Thr-Cys-Cys-Val-Ala-Lys-Ser-Tyr-Asn-Arg-Val-Thr-Val-Met-Gly-Gly-Phe-Lys-Val-Glu-Asn-His-Thr-Ala-Cys-His-Cys-Ser-Thr-Cys-Tyr-Tyr-His-Lys-Ser

Post-translational Modification
The production of biologically active FSH, LH and TSH requires the FSHβ, LHβ and TSHβ subunits and the common α subunits to assemble to form the heterodimeric hormone. The common α subunit is glycosylated at asparagines 52 and 78, and disulfide bond formation occurs between cysteine residues at positions 7 and 31; 10 and 60; 28 and 82; 32 and 84 and 59 and 87. It then assembles with the various β subunits to form the biologically active FSH, LH and TSH heterodimers.

Post-translational Modification

The production of biologically active FSH, LH and TSH requires the FSHβ, LHβ and TSHβ subunits and the common α subunits to assemble to form the heterodimeric hormone. The common α subunit is glycosylated at asparagines 52 and 78, and disulfide bond formation occurs between cysteine residues at positions 7 and 31; 10 and 60; 28 and 82; 32 and 84 and 59 and 87. It then assembles with the various β subunits to form the biologically active FSH, LH and TSH heterodimers.