rosuvastatin

Ligand id: 2954

Name: rosuvastatin

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View more information in the IUPHAR Pharmacology Education Project: rosuvastatin

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 3
Rotatable bonds 10
Topological polar surface area 149.3
Molecular weight 481.17
XLogP 2.43
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (2003))
IUPAC Name
(3R,5S)-7-[4-(4-fluorophenyl)-2-(methyl-methylsulfonylamino)-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid
International Nonproprietary Names
INN number INN
8021 rosuvastatin
Synonyms
Crestor® | ZD4522
Comments
Marketed formulations may contain rosuvastatin calcium (PubChem CID 5282455).
Database Links
CAS Registry No. 287714-41-4 (source: Scifinder)
ChEBI CHEBI:38545
ChEMBL Ligand CHEMBL1496
DrugBank Ligand DB01098
GtoPdb PubChem SID 135650928
PubChem CID 446157
Search Google for chemical match using the InChIKey BPRHUIZQVSMCRT-VEUZHWNKSA-N
Search Google for chemicals with the same backbone BPRHUIZQVSMCRT
Search PubMed clinical trials rosuvastatin
Search PubMed titles rosuvastatin
Search PubMed titles/abstracts rosuvastatin
Search UniChem for chemical match using the InChIKey BPRHUIZQVSMCRT-VEUZHWNKSA-N
Search UniChem for chemicals with the same backbone BPRHUIZQVSMCRT
Wikipedia Rosuvastatin