meta-chlorphenylbiguanide   Click here for help

GtoPdb Ligand ID: 2287

Abbreviated name: mCPBG
Synonyms: 1-(3-chlorophenyl)biguanide | 3-chlorophenyl-biguanide | m-chlorophenylbiguanide
Compound class: Synthetic organic
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 102.78
Molecular weight 211.06
XLogP 0.31
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES Clc1cccc(c1)N=C(N=C(N)N)N
Isomeric SMILES Clc1cccc(c1)N=C(N=C(N)N)N
InChI InChI=1S/C8H10ClN5/c9-5-2-1-3-6(4-5)13-8(12)14-7(10)11/h1-4H,(H6,10,11,12,13,14)
InChI Key DIHXJZHAIHGSAW-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Belelli D, Balcarek JM, Hope AG, Peters JA, Lambert JJ, Blackburn TP. (1995)
Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit.
Mol Pharmacol, 48 (6): 1054-62. [PMID:8848005]
2. Brady CA, Stanford IM, Ali I, Lin L, Williams JM, Dubin AE, Hope AG, Barnes NM. (2001)
Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors.
Neuropharmacology, 41 (2): 282-4. [PMID:11489465]
3. Davies PA, Pistis M, Hanna MC, Peters JA, Lambert JJ, Hales TG, Kirkness EF. (1999)
The 5-HT3B subunit is a major determinant of serotonin-receptor function.
Nature, 397 (6717): 359-63. [PMID:9950429]
4. Hope AG, Peters JA, Brown AM, Lambert JJ, Blackburn TP. (1996)
Characterization of a human 5-hydroxytryptamine3 receptor type A (h5-HT3R-AS) subunit stably expressed in HEK 293 cells.
Br J Pharmacol, 118 (5): 1237-45. [PMID:8818349]
5. Ito H, Kiso T, Miyata K, Kamato T, Yuki H, Akuzawa S, Nagakura Y, Yamano M, Suzuki M, Naitoh Y et al.. (2000)
Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro.
Eur J Pharmacol, 409 (2): 195-201. [PMID:11104834]
6. Lankiewicz S, Lobitz N, Wetzel CH, Rupprecht R, Gisselmann G, Hatt H. (1998)
Molecular cloning, functional expression, and pharmacological characterization of 5-hydroxytryptamine3 receptor cDNA and its splice variants from guinea pig.
Mol Pharmacol, 53 (2): 202-12. [PMID:9463477]
7. Mair ID, Lambert JJ, Yang J, Dempster J, Peters JA. (1998)
Pharmacological characterization of a rat 5-hydroxytryptamine type3 receptor subunit (r5-HT3A(b)) expressed in Xenopus laevis oocytes.
Br J Pharmacol, 124 (8): 1667-74. [PMID:9756382]
8. Miyake A, Mochizuki S, Takemoto Y, Akuzawa S. (1995)
Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species.
Mol Pharmacol, 48 (3): 407-16. [PMID:7565620]
9. Mochizuki S, Miyake A, Furuichi K. (1999)
Identification of a domain affecting agonist potency of meta-chlorophenylbiguanide in 5-HT3 receptors.
Eur J Pharmacol, 369 (1): 125-32. [PMID:10204690]
10. Niemeyer MI, Lummis SC. (1998)
Different efficacy of specific agonists at 5-HT3 receptor splice variants: the role of the extra six amino acid segment.
Br J Pharmacol, 123 (4): 661-6. [PMID:9517385]