meta-chlorphenylbiguanide [Ligand Id: 2287] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL13790 (3-Chloro-Phenyl Biguanide, M-Chlorophenylbiguanidine, N-(3-Chlorophenyl)Imidodicarbonimidic Diamide) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-HT3B/5-HT3A/Serotonin 3 (5-HT3) receptor in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111332] [GtoPdb: 374, 373] [UniProtKB: O95264, P46098] | ||||||||
| ChEMBL | Agonist activity at human 5-HT43AB receptor expressed in Xenopus laevis oocytes | B | 5.55 | pEC50 | 2800 | nM | EC50 | Bioorg Med Chem Lett (2017) 27: 3207-3218 [PMID:28606760] |
| 5-HT3A/Serotonin 3a (5-HT3a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098] | ||||||||
| ChEMBL | Agonist activity at human 5-HT43A receptor expressed in Xenopus laevis oocytes | B | 5.42 | pEC50 | 3800 | nM | EC50 | Bioorg Med Chem Lett (2017) 27: 3207-3218 [PMID:28606760] |
| 5-HT3A/Serotonin 3a (5-HT3a) receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4972] [GtoPdb: 373] [UniProtKB: P23979] | ||||||||
| ChEMBL | Selectivity ratio of EC50 for mouse 5HT3A I187A receptor mutant to EC50 for wild type mouse 5HT3A receptor | B | 4.18 | pEC50 | 66000 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Agonist activity at mouse 5HT3A I187A receptor mutant expressed in Xenopus oocyte by two-electrode voltage patch method | F | 4.28 | pEC50 | 52000 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Selectivity ratio of EC50 for mouse 5HT3A S182A receptor mutant to EC50 for wild type mouse 5HT3A receptor | B | 4.47 | pEC50 | 34000 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Agonist activity at mouse 5HT3A S182A receptor mutant expressed in Xenopus oocyte by two-electrode voltage patch method | F | 4.57 | pEC50 | 27000 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Selectivity ratio of EC50 for mouse 5HT3A W183F receptor mutant to EC50 for wild type mouse 5HT3A receptor | B | 4.7 | pEC50 | 20000 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Agonist activity at mouse 5HT3A W183F receptor mutant expressed in Xenopus oocyte by two-electrode voltage patch method | F | 4.8 | pEC50 | 16000 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Selectivity ratio of EC50 for mouse 5HT3A Y153A receptor mutant to EC50 for wild type mouse 5HT3A receptor | B | 5.02 | pEC50 | 9600 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Agonist activity at mouse 5HT3A Y153A receptor mutant expressed in Xenopus oocyte by two-electrode voltage patch method | F | 5.12 | pEC50 | 7600 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Selectivity ratio of EC50 for mouse 5HT3A H185Y receptor mutant to EC50 for wild type mouse 5HT3A receptor | B | 5.17 | pEC50 | 6800 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Selectivity ratio of EC50 for mouse 5HT3A Y143F receptor mutant to EC50 for wild type mouse 5HT3A receptor | B | 5.17 | pEC50 | 6700 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Selectivity ratio of EC50 for mouse 5HT3A L184V receptor mutant to EC50 for wild type mouse 5HT3A receptor | B | 5.19 | pEC50 | 6400 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Agonist activity at mouse 5HT3A H185Y receptor mutant expressed in Xenopus oocyte by two-electrode voltage patch method | F | 5.27 | pEC50 | 5400 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Agonist activity at mouse 5HT3A Y143F receptor mutant expressed in Xenopus oocyte by two-electrode voltage patch method | F | 5.28 | pEC50 | 5300 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Agonist activity at mouse 5HT3A L184V receptor mutant expressed in Xenopus oocyte by two-electrode voltage patch method | F | 5.29 | pEC50 | 5100 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Selectivity ratio of EC50 for mouse 5HT3A H185F receptor mutant to EC50 for wild type mouse 5HT3A receptor | B | 5.49 | pEC50 | 3200 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Selectivity ratio of EC50 for mouse 5HT3A Q188A receptor mutant to EC50 for wild type mouse 5HT3A receptor | B | 5.54 | pEC50 | 2900 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Selectivity ratio of EC50 for mouse 5HT3A Y153F receptor mutant to EC50 for wild type mouse 5HT3A receptor | B | 5.55 | pEC50 | 2800 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Selectivity ratio of EC50 for mouse 5HT3A T181A receptor mutant to EC50 for wild type mouse 5HT3A receptor | B | 5.55 | pEC50 | 2800 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Agonist activity at mouse 5HT3A H185F receptor mutant expressed in Xenopus oocyte by two-electrode voltage patch method | F | 5.6 | pEC50 | 2500 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Selectivity ratio of EC50 for mouse 5HT3A I190V receptor mutant to EC50 for wild type mouse 5HT3A receptor | B | 5.6 | pEC50 | 2500 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Agonist activity at mouse 5HT3A Q188A receptor mutant expressed in Xenopus oocyte by two-electrode voltage patch method | F | 5.64 | pEC50 | 2300 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Agonist activity at mouse 5HT3A Y153F receptor mutant expressed in Xenopus oocyte by two-electrode voltage patch method | F | 5.66 | pEC50 | 2200 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Agonist activity at mouse 5HT3A T181A receptor mutant expressed in Xenopus oocyte by two-electrode voltage patch method | F | 5.66 | pEC50 | 2200 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Selectivity ratio of EC50 for mouse 5HT3A T186A receptor mutant to EC50 for wild type mouse 5HT3A receptor | B | 5.66 | pEC50 | 2200 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Agonist activity at mouse 5HT3A I190V receptor mutant expressed in Xenopus oocyte by two-electrode voltage patch method | F | 5.7 | pEC50 | 2000 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Agonist activity at mouse 5HT3A T186A receptor mutant expressed in Xenopus oocyte by two-electrode voltage patch method | F | 5.77 | pEC50 | 1700 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| ChEMBL | Agonist activity at wild type mouse 5HT3A receptor expressed in Xenopus oocyte by two-electrode voltage patch clamp method | F | 6.1 | pEC50 | 800 | nM | EC50 | Bioorg Med Chem (2009) 17: 5796-5805 [PMID:19640719] |
| TAAR5/Trace amine-associated receptor 5 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3784908] [GtoPdb: 170] [UniProtKB: Q5QD14] | ||||||||
| ChEMBL | Agonist activity at mouse TAAR5 expressed in HEK293 cells assessed as cAMP accumulation after 20 mins by BRET assay | F | 5 | pEC50 | >10000 | nM | EC50 | Eur J Med Chem (2017) 127: 781-792 [PMID:27823885] |
| 5-HT3AB in Human [GtoPdb: 378] | ||||||||
| GtoPdb | - | - | 7 | pKi | - | - | - | Neuropharmacology (2001) 41: 282-4 [PMID:11489465] |
| GtoPdb | - | - | 5.7 | pEC50 | - | - | - | Nature (1999) 397: 359-63 [PMID:9950429] |
| 5-HT3A in Human [GtoPdb: 379] | ||||||||
| GtoPdb | - | - | 7.2 | pKi | - | - | - |
Mol Pharmacol (1995) 48: 407-16 [PMID:7565620]; Mol Pharmacol (1998) 53: 202-12 [PMID:9463477]; Neuropharmacology (2001) 41: 282-4 [PMID:11489465]; Br J Pharmacol (1996) 118: 1237-45 [PMID:8818349]; Eur J Pharmacol (2000) 409: 195-201 [PMID:11104834] |
| GtoPdb | - | - | 5.8 | pEC50 | 1600 | nM | EC50 |
Nature (1999) 397: 359-63 [PMID:9950429]; Mol Pharmacol (1995) 48: 1054-62 [PMID:8848005]; Mol Pharmacol (1995) 48: 407-16 [PMID:7565620]; Mol Pharmacol (1998) 53: 202-12 [PMID:9463477]; Eur J Pharmacol (1999) 369: 125-32 [PMID:10204690] |
| 5-HT3A in Rat [GtoPdb: 379] | ||||||||
| GtoPdb | - | - | 9 | pKi | - | - | - |
Mol Pharmacol (1995) 48: 407-16 [PMID:7565620]; Br J Pharmacol (1998) 123: 661-6 [PMID:9517385] |
| GtoPdb | - | - | 6.9 | pEC50 | - | - | - |
Br J Pharmacol (1998) 124: 1667-74 [PMID:9756382]; Eur J Pharmacol (1999) 369: 125-32 [PMID:10204690] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
