Bioactivity Comments

OBT076 induces killing of CD205+ve cells. This includes the target tumour cells, and also includes a subpopulation of immunosuppressive dendritic cells. So in addition to a direct anti-tumour activity, OBT076 may also reactivate an anti-tumour immune response. The ADC binds human and cynomolgus CD205 with comparable potency, but does not cross react with rat or mouse CD205.

Selectivity at other protein targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference lymphocyte antigen 75 Hs Antibody Binding - - - 2 ⤷ [2]