C6-Quino 
GtoPdb Ligand ID: 13817
|
Compound class:
Synthetic organic
Comment: C6-Quino is a naltrindole derivative. It has been optimised as a biased partial agonist of the δ opioid receptor [1]. It interacts with the orthosteric binding site and with the receptor's allosteric sodium binding pocket. C6-Quino demonstrates bias towards G protein signalling (preferentially recruiting Gi1) compared to β-arrestin recruitment. Antinociceptive activity has been observed in rodent models of chronic pain of various etiologies.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
|
|||||||||||||||||||||||||||||||||||
For advanced searching click here to open chemical structure editor
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License