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foslevodopa   Click here for help

GtoPdb Ligand ID: 13174

Synonyms: Dopa 4-phosphate
Approved drug
foslevodopa is an approved drug (EMA (2022))
Compound class: Synthetic organic
Comment: Foslevodopa is a water-soluble levodopa prodrug.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 8
Hydrogen bond donors 5
Rotatable bonds 5
Topological polar surface area 160.12
Molecular weight 277.17
XLogP -4.49
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C1=C(C[C@@H](C(=O)O)N)C=C(C(=C1)OP(=O)(O)O)O
Isomeric SMILES C1=CC(=C(C=C1C[C@@H](C(=O)O)N)O)OP(=O)(O)O
InChI InChI=1S/C9H12NO7P/c10-6(9(12)13)3-5-1-2-8(7(11)4-5)17-18(14,15)16/h1-2,4,6,11H,3,10H2,(H,12,13)(H2,14,15,16)/t6-/m0/s1
InChI Key YNDMEEULGSTYJT-LURJTMIESA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. EU EMA (2022)
Is prodrug? Yes
Active form levodopa
IUPAC Name Click here for help
(2S)-2-amino-3-(3-hydroxy-4-phosphonooxyphenyl)propanoic acid
International Nonproprietary Names Click here for help
INN number INN
11006 foslevodopa
Synonyms Click here for help
Dopa 4-phosphate
Database Links Click here for help
CAS Registry No. 97321-87-4 (source: WHO INN record)
ChEBI CHEBI:192509
ChEMBL Ligand CHEMBL4594379
GtoPdb PubChem SID 491299956
PubChem CID 127766
Search Google for chemical match using the InChIKey YNDMEEULGSTYJT-LURJTMIESA-N
Search Google for chemicals with the same backbone YNDMEEULGSTYJT
Search PubMed clinical trials foslevodopa
Search PubMed titles foslevodopa
Search PubMed titles/abstracts foslevodopa
UniChem Compound Search for chemical match using the InChIKey YNDMEEULGSTYJT-LURJTMIESA-N
UniChem Connectivity Search for chemical match using the InChIKey YNDMEEULGSTYJT-LURJTMIESA-N