FHD-609   Click here for help

GtoPdb Ligand ID: 12759

Synonyms: Compound S-D1 [WO2021155225A1] | FHD609
Compound class: Synthetic organic
Comment: FHD-609 is a PROTAC degrader of bromodomain-containing protein 9 (BRD9), that was designed as a treatment for synovial sarcoma and SMARCB1-loss tumours. It is one of the compounds claimed in Foghorn Therapeutics' patent WO2021155225A1 [1]. FHD-609 is suitable for intravenous delivery.

FHD-609 is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 14
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 130.57
Molecular weight 829
XLogP 1.77
No. Lipinski's rules broken 2

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CN1C=C(C2=CC(=C(CN3CCC(CC3)CN4CCC5(CC4)CN(C5)C6=CC=C7CN([C@@]8([H])CCC(=O)NC8=O)C(=O)C7=C6)C(=C2)OC)OC)C9=C(C=NC(=C9)N%10CCC%10)C1=O
Isomeric SMILES [H][C@@]1(CCC(=O)NC1=O)N2CC3=C(C=C(C=C3)N4CC5(C4)CCN(CC6CCN(CC7=C(OC)C=C(C=C7OC)C8=CN(C)C(=O)C9=C8C=C(N=C9)N%10CCC%10)CC6)CC5)C2=O
InChI InChI=1S/C47H56N8O6/c1-50-26-37(35-22-42(53-13-4-14-53)48-23-36(35)45(50)58)32-19-40(60-2)38(41(20-32)61-3)27-51-15-9-30(10-16-51)24-52-17-11-47(12-18-52)28-54(29-47)33-6-5-31-25-55(46(59)34(31)21-33)39-7-8-43(56)49-44(39)57/h5-6,19-23,26,30,39H,4,7-18,24-25,27-29H2,1-3H3,(H,49,56,57)/t39-/m0/s1
InChI Key OBNRBCUHEAAFPS-KDXMTYKHSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
No information available.
Summary of Clinical Use Click here for help
FHD-609 has progressed to the initial stage of clinical evaluation.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT04965753 FHD-609 in Subjects With Advanced Synovial Sarcoma or Advanced SMARCB1-Loss Tumors Phase 1 Interventional Foghorn Therapeutics Inc.