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FHD-609   Click here for help

GtoPdb Ligand ID: 12759

Synonyms: Compound S-D1 [WO2021155225A1] | FHD609
Compound class: Synthetic organic
Comment: FHD-609 is a PROTAC degrader of bromodomain-containing protein 9 (BRD9), that was designed as a treatment for synovial sarcoma and SMARCB1-loss tumours. It is one of the compounds claimed in Foghorn Therapeutics' patent WO2021155225A1 [1]. FHD-609 is suitable for intravenous delivery.

FHD-609 is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 14
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 130.57
Molecular weight 829
XLogP 1.77
No. Lipinski's rules broken 2

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CN1C=C(C2=CC(=C(CN3CCC(CC3)CN4CCC5(CC4)CN(C5)C6=CC=C7CN([C@@]8([H])CCC(=O)NC8=O)C(=O)C7=C6)C(=C2)OC)OC)C9=C(C=NC(=C9)N%10CCC%10)C1=O
Isomeric SMILES [H][C@@]1(CCC(=O)NC1=O)N2CC3=C(C=C(C=C3)N4CC5(C4)CCN(CC6CCN(CC7=C(OC)C=C(C=C7OC)C8=CN(C)C(=O)C9=C8C=C(N=C9)N%10CCC%10)CC6)CC5)C2=O
InChI InChI=1S/C47H56N8O6/c1-50-26-37(35-22-42(53-13-4-14-53)48-23-36(35)45(50)58)32-19-40(60-2)38(41(20-32)61-3)27-51-15-9-30(10-16-51)24-52-17-11-47(12-18-52)28-54(29-47)33-6-5-31-25-55(46(59)34(31)21-33)39-7-8-43(56)49-44(39)57/h5-6,19-23,26,30,39H,4,7-18,24-25,27-29H2,1-3H3,(H,49,56,57)/t39-/m0/s1
InChI Key OBNRBCUHEAAFPS-KDXMTYKHSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Ligand families/groups PROTACs, molecular glues and other degraders
IUPAC Name Click here for help
(3S)-3-[5-[7-[[1-[[4-[6-(azetidin-1-yl)-2-methyl-1-oxo-2,7-naphthyridin-4-yl]-2,6-dimethoxyphenyl]methyl]piperidin-4-yl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione
Synonyms Click here for help
Compound S-D1 [WO2021155225A1] | FHD609
Database Links Click here for help
GtoPdb PubChem SID 483123307
PubChem CID 156817975
Search Google for chemical match using the InChIKey OBNRBCUHEAAFPS-KDXMTYKHSA-N
Search Google for chemicals with the same backbone OBNRBCUHEAAFPS
UniChem Compound Search for chemical match using the InChIKey OBNRBCUHEAAFPS-KDXMTYKHSA-N
UniChem Connectivity Search for chemical match using the InChIKey OBNRBCUHEAAFPS-KDXMTYKHSA-N

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MedChemExpress
FHD-609 (links to external site)
Cat. No. HY-153367