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durlobactam   Click here for help

GtoPdb Ligand ID: 12693

Synonyms: ETX-2514 | EXT2514 | Xacduro® (sulbactam and durlobactam)
Approved drug
durlobactam is an approved drug (FDA (2023))
Compound class: Synthetic organic
Comment: Durlobactam (ETX2514) is a broad-spectrum diazabicyclooctanone (DBO) class non-beta-lactam beta-lactamase inhibitor [1]. It reduces beta-lactamase-mediated degradation of beta-lactam antibacterials, and has been demonstrated to restore sulbactam activity against Acinetobacter species, including contemporary multidrug-resistant strains [4]. There is evidence that a few carbapenem- and colistin-resistant, metallo beta-lactamase (MBL)-producing strains of A. baumannii are resistant to sulbactam/durlobactam dual therapy [2,5].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 138.62
Molecular weight 277.26
XLogP -3.64
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CC1=C[C@@H]2CN([C@@H]1C(=O)N)C(=O)N2OS(=O)(=O)O
Isomeric SMILES CC1=C[C@@H]2CN([C@@H]1C(=O)N)C(=O)N2OS(=O)(=O)O
InChI InChI=1S/C8H11N3O6S/c1-4-2-5-3-10(6(4)7(9)12)8(13)11(5)17-18(14,15)16/h2,5-6H,3H2,1H3,(H2,9,12)(H,14,15,16)/t5-,6+/m1/s1
InChI Key BISPBXFUKNXOQY-RITPCOANSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. US FDA (2023)
International Nonproprietary Names Click here for help
INN number INN
10824 durlobactam
Synonyms Click here for help
ETX-2514 | EXT2514 | Xacduro® (sulbactam and durlobactam)
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Durlobactam
Other databases
CAS Registry No. 1467829-71-5 (source: WHO INN record)
ChEMBL Ligand CHEMBL4298137
DrugBank Ligand DB16704
GtoPdb PubChem SID 483123241
PubChem CID 89851852
Search Google for chemical match using the InChIKey BISPBXFUKNXOQY-RITPCOANSA-N
Search Google for chemicals with the same backbone BISPBXFUKNXOQY
Search PubMed clinical trials durlobactam
Search PubMed titles durlobactam
Search PubMed titles/abstracts durlobactam
UniChem Compound Search for chemical match using the InChIKey BISPBXFUKNXOQY-RITPCOANSA-N
UniChem Connectivity Search for chemical match using the InChIKey BISPBXFUKNXOQY-RITPCOANSA-N