rimtuzalcap   Click here for help

GtoPdb Ligand ID: 12649

Synonyms: CAD-1883 | CAD1883 | compound 1 [US9975886B1]
Compound class: Synthetic organic
Comment: Rimtuzalcap (CAD-1883) is a KCa2 channel activator (positive allosteric modulator) [1], that was developed for potential to treat movement disorders such as essential tremor and spinocerebellar ataxia.

rimtuzalcap is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 64.82
Molecular weight 378.42
XLogP 2.43
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CC1=NN(C=C1)C2=NC(=CC(=N2)NC3CCC(CC3)(F)F)N4CCOCC4
Isomeric SMILES CC1=NN(C=C1)C2=NC(=CC(=N2)N3CCOCC3)NC4CCC(CC4)(F)F
InChI InChI=1S/C18H24F2N6O/c1-13-4-7-26(24-13)17-22-15(21-14-2-5-18(19,20)6-3-14)12-16(23-17)25-8-10-27-11-9-25/h4,7,12,14H,2-3,5-6,8-11H2,1H3,(H,21,22,23)
InChI Key OVLIDRAJVMUEMC-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
N-(4,4-difluorocyclohexyl)-2-(3-methylpyrazol-1-yl)-6-morpholin-4-ylpyrimidin-4-amine
International Nonproprietary Names Click here for help
INN number INN
11140 rimtuzalcap
Synonyms Click here for help
CAD-1883 | CAD1883 | compound 1 [US9975886B1]
Database Links Click here for help
CAS Registry No. 2167246-24-2 (source: WQHO INN record)
ChEMBL Ligand CHEMBL4650330
GtoPdb PubChem SID 483123197
PubChem CID 132207249
Search Google for chemical match using the InChIKey OVLIDRAJVMUEMC-UHFFFAOYSA-N
Search Google for chemicals with the same backbone OVLIDRAJVMUEMC
Search PubMed clinical trials rimtuzalcap
Search PubMed titles rimtuzalcap
Search PubMed titles/abstracts rimtuzalcap
UniChem Compound Search for chemical match using the InChIKey OVLIDRAJVMUEMC-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey OVLIDRAJVMUEMC-UHFFFAOYSA-N

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MedChemExpress
Rimtuzalcap (links to external site)
Cat. No. HY-109160