ontorpacept 
GtoPdb Ligand ID: 12036
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Synonyms: TTI-621 | TTI621
Compound class:
Peptide
Comment: Ontorpacept (TTI-621) is a 345 amino acid fusion protein that consists of the N-terminal V domain of human SIRPα fused to the Fc region of human IgG1 that was designed as an immuno-oncology agent [1]. The SIRPα domain binds to CD47 on cancer cells (to block the CD47-SIRPα anti-phagocytic signal). Inclusion of the IgG1 Fc region enhances phagocytosis of malignant cells via interaction with Fcγ receptors.
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Other Similar Sequences  |
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| IL-22 {Sp: Human} |
TargetsInterleukin-22α1/10β heteromer |
| dulaglutide | |
| olamkicept |
Targetsnull |
| evorpacept |
TargetsCD47 |
| efmarodocokin alfa |
TargetsInterleukin-22α1/10β heteromer |
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