HU-580   Click here for help

GtoPdb Ligand ID: 10599

Synonyms: cannabidiolic acid methyl ester | CBDA-ME | HU580
Compound class: Synthetic organic
Comment: HU-580 (cannabidiolic acid methyl ester; CBDA-ME) is a stable synthetic analogue of the naturally occurring phytocannabinoid, cannabidiolic acid (CBDA ) [1]. HU-580 has been shown to enhance maximal agonist activation of 5-HT1A receptors in a rat model, and produces anti-nausea and anti-anxiety effects which align with the biological profile reported for CBDA. The compound has efficacy in a rat model of peripheral neuropathic pain when administered at an early stage post-sciatic nerve surgery [2]. Interestingly this effect is only observed in male rats, indicating potential sexual dimorphism in this response.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 77.76
Molecular weight 372.23
XLogP 6.23
No. Lipinski's rules broken 1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CCCCCc1cc(O)c(c(c1CC(=O)O)O)C1C=C(C)CCC1C(=C)C
Isomeric SMILES CCCCCc1cc(O)c(c(c1CC(=O)O)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C
InChI InChI=1S/C23H32O4/c1-5-6-7-8-16-12-20(24)22(23(27)18(16)13-21(25)26)19-11-15(4)9-10-17(19)14(2)3/h11-12,17,19,24,27H,2,5-10,13H2,1,3-4H3,(H,25,26)/t17-,19+/m0/s1
InChI Key BOYRUNMTTPSTKZ-PKOBYXMFSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
2-{2,4-dihydroxy-3-[(1R,6R)-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]-6-pentylphenyl}acetic acid
Synonyms Click here for help
cannabidiolic acid methyl ester | CBDA-ME | HU580
Database Links Click here for help
GtoPdb PubChem SID 404859046
PubChem CID 145996527
Search Google for chemical match using the InChIKey BOYRUNMTTPSTKZ-PKOBYXMFSA-N
Search Google for chemicals with the same backbone BOYRUNMTTPSTKZ
UniChem Compound Search for chemical match using the InChIKey BOYRUNMTTPSTKZ-PKOBYXMFSA-N
UniChem Connectivity Search for chemical match using the InChIKey BOYRUNMTTPSTKZ-PKOBYXMFSA-N