ChEMBL ligand: CHEMBL1242950 (AC-42)
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] There should be some charts here, you may need to enable JavaScript!
A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] There should be some charts here, you may need to enable JavaScript!
A2A receptor/Adenosine A2a receptor in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] There should be some charts here, you may need to enable JavaScript!
A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] There should be some charts here, you may need to enable JavaScript!
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348] There should be some charts here, you may need to enable JavaScript!
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368] There should be some charts here, you may need to enable JavaScript!
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100] There should be some charts here, you may need to enable JavaScript!
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913] There should be some charts here, you may need to enable JavaScript!
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089] There should be some charts here, you may need to enable JavaScript!
β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] There should be some charts here, you may need to enable JavaScript!
β2-adrenoceptor/Beta-2 adrenergic receptor in Human [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] There should be some charts here, you may need to enable JavaScript!
CB1 receptor/Cannabinoid CB1 receptor in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] There should be some charts here, you may need to enable JavaScript!
CCK2 receptor/Cholecystokinin B receptor in Human [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239] There should be some charts here, you may need to enable JavaScript!
D1 receptor/Dopamine D1 receptor in Human [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] There should be some charts here, you may need to enable JavaScript!
D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] There should be some charts here, you may need to enable JavaScript!
D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] There should be some charts here, you may need to enable JavaScript!
D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] There should be some charts here, you may need to enable JavaScript!
DAT/Dopamine transporter in Human [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959] There should be some charts here, you may need to enable JavaScript!
ETA receptor/Endothelin receptor ET-A in Human [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101] There should be some charts here, you may need to enable JavaScript!
Glucocorticoid receptor in Human [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150] There should be some charts here, you may need to enable JavaScript!
CHT/High-affinity choline transporter in Human [ChEMBL: CHEMBL4507] [GtoPdb: 914] [UniProtKB: Q9GZV3] There should be some charts here, you may need to enable JavaScript!
H1 receptor/Histamine H1 receptor in Human [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367] There should be some charts here, you may need to enable JavaScript!
H2 receptor/Histamine H2 receptor in Human [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021] There should be some charts here, you may need to enable JavaScript!
H3 receptor/Histamine H3 receptor in Human [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] There should be some charts here, you may need to enable JavaScript!
MC4 receptor/Melanocortin receptor 4 in Human [ChEMBL: CHEMBL259] [GtoPdb: 285] [UniProtKB: P32245] There should be some charts here, you may need to enable JavaScript!
MT1 receptor/Melatonin receptor 1A in Human [ChEMBL: CHEMBL1945] [GtoPdb: 287] [UniProtKB: P48039] There should be some charts here, you may need to enable JavaScript!
Monoamine oxidase A in Human [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!
M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229] There should be some charts here, you may need to enable JavaScript!
M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172] There should be some charts here, you may need to enable JavaScript!
M3 receptor/Muscarinic acetylcholine receptor M3 in Human [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309] There should be some charts here, you may need to enable JavaScript!
M4 receptor/Muscarinic acetylcholine receptor M4 in Human [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173] There should be some charts here, you may need to enable JavaScript!
M5 receptor/Muscarinic acetylcholine receptor M5 in Human [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912] There should be some charts here, you may need to enable JavaScript!
NK1 receptor/Neurokinin 1 receptor in Human [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103] There should be some charts here, you may need to enable JavaScript!
NK2 receptor/Neurokinin 2 receptor in Human [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452] There should be some charts here, you may need to enable JavaScript!
nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α4 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Human [ChEMBL: CHEMBL1907589] [GtoPdb: 472, 465] [UniProtKB: P17787, P43681] There should be some charts here, you may need to enable JavaScript!
Y1 receptor/Neuropeptide Y receptor type 1 in Human [ChEMBL: CHEMBL4777] [GtoPdb: 305] [UniProtKB: P25929] There should be some charts here, you may need to enable JavaScript!
NTS1 receptor/Neurotensin receptor 1 in Human [ChEMBL: CHEMBL4123] [GtoPdb: 309] [UniProtKB: P30989] There should be some charts here, you may need to enable JavaScript!
Nischarin in Human [ChEMBL: CHEMBL3923] [UniProtKB: Q9Y2I1] There should be some charts here, you may need to enable JavaScript!
NET/Norepinephrine transporter in Human [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975] There should be some charts here, you may need to enable JavaScript!
Quinone reductase 2 in Human [ChEMBL: CHEMBL3959] [UniProtKB: P16083] There should be some charts here, you may need to enable JavaScript!
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] There should be some charts here, you may need to enable JavaScript!
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222] There should be some charts here, you may need to enable JavaScript!
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] There should be some charts here, you may need to enable JavaScript!
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] There should be some charts here, you may need to enable JavaScript!
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] There should be some charts here, you may need to enable JavaScript!
5-HT3A/Serotonin 3a (5-HT3a) receptor in Human [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098] There should be some charts here, you may need to enable JavaScript!
5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Human [ChEMBL: CHEMBL1875] [GtoPdb: 9] [UniProtKB: Q13639] There should be some charts here, you may need to enable JavaScript!
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969] There should be some charts here, you may need to enable JavaScript!
SERT/Serotonin transporter in Human [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] There should be some charts here, you may need to enable JavaScript!
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
ChEMBL	Binding affinity to human acetylcholine esterase by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
ChEMBL	Binding affinity to human adenosine A1 receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
ChEMBL	Binding affinity to human adenosine A1 receptor agonist site by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
ChEMBL	Binding affinity to human adenosine A2A receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
ChEMBL	Binding affinity to human adenosine A3 receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
ChEMBL	Binding affinity to human adrenergic alpha1A receptor by radioligand displacement assay	B	7.74	pKi	18	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368]
ChEMBL	Binding affinity to human adrenergic Alpha-1B receptor by radioligand displacement assay	B	7.19	pKi	65	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
ChEMBL	Binding affinity to human adrenergic Alpha-1D receptor by radioligand displacement assay	B	7.4	pKi	40	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
ChEMBL	Binding affinity to human adrenergic alpha2A receptor by radioligand displacement assay	B	6.28	pKi	530	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
ChEMBL	Binding affinity to adrenergic alpha2B receptor by radioligand displacement assay	B	6.08	pKi	840	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
ChEMBL	Binding affinity to human adrenergic beta-1 receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
ChEMBL	Binding affinity to adrenergic beta2 receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
ChEMBL	Binding affinity to human CB1 receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
CCK2 receptor/Cholecystokinin B receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239]
ChEMBL	Binding affinity to human CCK2 receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
ChEMBL	Binding affinity to human dopamine D1 receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL	Binding affinity to human D2S agonist site receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
ChEMBL	Binding affinity to human dopamine D2S receptor by radioligand displacement assay	B	7.11	pKi	77	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
ChEMBL	Binding affinity to human dopamine D3 receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
ChEMBL	Binding affinity to human D4.4 receptor by radioligand displacement assay	B	7.96	pKi	11	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959]
ChEMBL	Binding affinity to human dopamine transporter by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
ETA receptor/Endothelin receptor ET-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101]
ChEMBL	Binding affinity to human ETA receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
Glucocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150]
ChEMBL	Binding affinity to human glucocorticoid receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
CHT/High-affinity choline transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4507] [GtoPdb: 914] [UniProtKB: Q9GZV3]
ChEMBL	Binding affinity to human choline transporter (CHT1) by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
H1 receptor/Histamine H1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367]
ChEMBL	Binding affinity to human histamine H1 receptor by radioligand displacement assay	B	6.21	pKi	610	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
H2 receptor/Histamine H2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021]
ChEMBL	Binding affinity to human histamine H2 receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
H3 receptor/Histamine H3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1]
ChEMBL	Binding affinity to human histamine H3 receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Binding affinity to kappa opioid receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL	Binding affinity to p38alpha by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
MC4 receptor/Melanocortin receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL259] [GtoPdb: 285] [UniProtKB: P32245]
ChEMBL	Binding affinity to human MC4 receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
MT1 receptor/Melatonin receptor 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1945] [GtoPdb: 287] [UniProtKB: P48039]
ChEMBL	Binding affinity to human MT1 receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
Monoamine oxidase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397]
ChEMBL	Binding affinity to MAOA by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Binding affinity to human mu opioid receptor agonist site by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
ChEMBL	Binding affinity to human muscarinic M1 receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
GtoPdb	-	-	6.2	pKi	-	-	-	Mol Pharmacol (2006) 69: 236-46 [PMID:16207821]
GtoPdb	-	-	6.2	pKi	-	-	-	Mol Pharmacol (2006) 69: 236-46 [PMID:16207821]
ChEMBL	Agonist activity at human muscarinic M1 receptor Y381A mutant expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	F	6.3	pEC50	500	nM	EC50	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
ChEMBL	Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	F	6.82	pEC50	150	nM	EC50	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
ChEMBL	Binding affinity to human muscarinic M2 receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
ChEMBL	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	B	6.01	pKi	980	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
ChEMBL	Displacement of [3H]-4-DAMP from human muscarinic M3 receptor expressed in BHK-21 cells	B	5.55	pKi	2800	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
ChEMBL	Binding affinity to human muscarinic M3 receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
M4 receptor/Muscarinic acetylcholine receptor M4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
ChEMBL	Displacement of [3H]-4-DAMP from human muscarinic M4 receptor expressed in BHK-21 cells	B	5.85	pKi	1400	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
ChEMBL	Binding affinity to human muscarinic M4 receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
M5 receptor/Muscarinic acetylcholine receptor M5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
ChEMBL	Displacement of [3H]-4-DAMP from human muscarinic M5 receptor expressed in BHK-21 cells	B	5.35	pKi	4500	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
ChEMBL	Binding affinity to human muscarinic M5 receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
NK1 receptor/Neurokinin 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103]
ChEMBL	Binding affinity to human NK1 receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
NK2 receptor/Neurokinin 2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452]
ChEMBL	Binding affinity to human NK2 receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α4 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907589] [GtoPdb: 472, 465] [UniProtKB: P17787, P43681]
ChEMBL	Binding affinity to nAChR alpha4beta2 receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
Y1 receptor/Neuropeptide Y receptor type 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4777] [GtoPdb: 305] [UniProtKB: P25929]
ChEMBL	Binding affinity to human neuropeptide Y1 receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
NTS1 receptor/Neurotensin receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4123] [GtoPdb: 309] [UniProtKB: P30989]
ChEMBL	Binding affinity to human UT1 receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
Nischarin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3923] [UniProtKB: Q9Y2I1]
ChEMBL	Binding affinity to I1 receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
ChEMBL	Binding affinity to human NE transporter by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
Quinone reductase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3959] [UniProtKB: P16083]
ChEMBL	Binding affinity to ML2 (MT3) receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL	Binding affinity to human 5-HT1A receptor by radioligand displacement assay	B	6.55	pKi	280	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
ChEMBL	Binding affinity to 5-HT1B receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
ChEMBL	Binding affinity to human 5-HT2A agonist site receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
ChEMBL	Binding affinity to human 5-HT2B agonist site receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL	Binding affinity to human 5HT2C receptor agonist site by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
5-HT3A/Serotonin 3a (5-HT3a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098]
ChEMBL	Binding affinity to human 5-HT3 receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1875] [GtoPdb: 9] [UniProtKB: Q13639]
ChEMBL	Binding affinity to human 5-HT4e receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
ChEMBL	Binding affinity to human 5-HT7 receptor by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
ChEMBL	Binding affinity to human 5-HT transporter by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
ChEMBL	Binding affinity to Lyn by radioligand displacement assay	B	6	pKi	>=1000	nM	Ki	J Med Chem (2010) 53: 6386-6397 [PMID:20684563]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]