Top ▲

Adenosine turnover C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


Click here for help

« Hide More detailed introduction go icon to follow link

A multifunctional, ubiquitous molecule, adenosine acts at cell-surface G protein-coupled receptors, as well as numerous enzymes, including protein kinases and adenylyl cyclase. Extracellular adenosine is thought to be produced either by export or by metabolism, predominantly through ecto-5’-nucleotidase activity (also producing inorganic phosphate). It is inactivated either by extracellular metabolism via adenosine deaminase (also producing ammonia) or, following uptake by nucleoside transporters, via adenosine deaminase or adenosine kinase (requiring ATP as co-substrate). Intracellular adenosine may be produced by cytosolic 5’-nucleotidases or through S-adenosylhomocysteine hydrolase (also producing L-homocysteine).


Click here for help

ADA (Adenosine deaminase) C Show summary » More detailed page go icon to follow link

ADK (Adenosine kinase) C Show summary »

NT5E (Ecto-5'-Nucleotidase / CD73) C Show summary » More detailed page go icon to follow link

SAHH (S-Adenosylhomocysteine hydrolase) C Show summary »

Target Id 1233
Nomenclature S-Adenosylhomocysteine hydrolase
Common abbreviation SAHH
Previous and unofficial names Adenosylhomocysteinase | adoHcyase | CuBP
Genes AHCY (Hs), Ahcy (Mm), Ahcy (Rn)
Ensembl ID ENSG00000101444 (Hs), ENSMUSG00000027597 (Mm), ENSRNOG00000017777 (Rn)
UniProtKB AC P23526 (Hs), P50247 (Mm), P10760 (Rn)
EC number
Endogenous substrates S-adenosylhomocysteine
DZNep pKi 12.3 [5] - Hamster
Selective inhibitors
3-deazaadenosine pIC50 8.5 [6]

5'-nucleotidase IA Show summary »

5'-nucleotidase IB Show summary »

5'-nucleotidase II Show summary »

5'-nucleotidase III Show summary »

5'(3')-nucleotidase Show summary »

Mitochondrial 5'-nucleotidase Show summary »


Click here for help

Show »

Further reading

Click here for help

Show »


Click here for help

Show »

NC-IUPHAR subcommittee and family contributors

Show »

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.