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NRAMP1

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Target id: 966

Nomenclature: NRAMP1

Systematic Nomenclature: SLC11A1

Family: SLC11 family of proton-coupled metal ion transporters

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 12 550 2q35 SLC11A1 solute carrier family 11 member 1
Mouse 12 548 1 38.54 cM Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Rat 10 507 9q33 Slc11a1 solute carrier family 11 member 1
Previous and Unofficial Names Click here for help
LSH | NRAMP | Ity | Bcg | Itg | natural resistance associated macrophage protein 1 | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 | solute carrier family 11 (proton-coupled divalent metal ion transporters)
Database Links Click here for help
Specialist databases
Bioparadigms SLC Tables SLC11A1 (Hs)
RESOLUTE SLC11A1 (Hs)
Other databases
Alphafold P49279 (Hs), P41251 (Mm), P70553 (Rn)
ChEMBL Target CHEMBL2052040 (Hs)
Ensembl Gene ENSG00000018280 (Hs), ENSMUSG00000026177 (Mm), ENSRNOG00000014956 (Rn)
Entrez Gene 6556 (Hs), 18173 (Mm), 316519 (Rn)
Human Protein Atlas ENSG00000018280 (Hs)
KEGG Gene hsa:6556 (Hs), mmu:18173 (Mm), rno:316519 (Rn)
OMIM 600266 (Hs)
Pharos P49279 (Hs)
UniProtKB P49279 (Hs), P41251 (Mm), P70553 (Rn)
Wikipedia SLC11A1 (Hs)
Substrates and Reaction Kinetics Click here for help
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
Fe2+ Substrate is endogenous in the given species Hs - -
Mn2+ Substrate is endogenous in the given species Hs - -
Stoichiometry Click here for help
1 H+ : 1 Fe2+ (out) or 1 Fe2+ (in) : 1 H+ (out)
Immunopharmacology Comments
NRAMP1 / SLC11A1 appears to be involved in macrophage antimicrobial action against intracellular pathogens, and although its precise mechanism is not fully resolved, evidence indicates its involvement in the activation of phagocytes and synthesis of proinflammatory cytokines. Polymorphisms in the human SLC11A1 gene have been associated with susceptibility to several infections [1,3-4], and more recently in genetic susceptibility to development of rheumatoid arthritis [2] (describing a protective role for the SLC11A1D543N variant in the tested population) .
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Antigen presentation
Immuno Process:  T cell (activation)
Immuno Process:  B cell (activation)
Immuno Process:  Immune regulation
Immuno Process:  Cytokine production & signalling
Immuno Process:  Cellular signalling

References

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1. Brochado MJ, Gatti MF, Zago MA, Roselino AM. (2016) Association of the solute carrier family 11 member 1 gene polymorphisms with susceptibility to leprosy in a Brazilian sample. Mem Inst Oswaldo Cruz, 111 (2): 101-5. [PMID:26814595]

2. Niño-Moreno P, Turrubiartes-Martínez E, Oceguera-Maldonado B, Baltazar-Benítez N, Negrete-González C, Oliva-Ramírez B, Baranda L, González-Amaro R. (2017) The Role of NRAMP1/SLC11A1 Gene Variant D543N (1730G/A) in the Genetic Susceptibility to Develop Rheumatoid Arthritis in the Mexican Mestizo population. Rev Invest Clin, 69 (1): 5-10. [PMID:28239176]

3. Somuk BT, Koc S, Ates O, Göktas G, Soyalic H, Uysal IO, Gurbuzler L, Sapmaz E, Sezer S, Eyibilen A. (2016) MBL, P2X7, and SLC11A1 gene polymorphisms in patients with oropharyngeal tularemia. Acta Otolaryngol, 136 (11): 1168-1172. [PMID:27223255]

4. Sophie M, Hameed A, Muneer A, Samdani AJ, Saleem S, Azhar A. (2017) SLC11A1 polymorphisms and host susceptibility to cutaneous leishmaniasis in Pakistan. Parasit Vectors, 10 (1): 12. [PMID:28061874]

How to cite this page

SLC11 family of proton-coupled metal ion transporters: NRAMP1. Last modified on 19/04/2017. Accessed on 24/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=966.