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Target id: 780

Nomenclature: ABCC2

Abbreviated Name: MRP2, cMOAT

Systematic Nomenclature: ABCC2

Family: ABCC subfamily

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 17 1545 10q24.2 ABCC2 ATP binding cassette subfamily C member 2
Mouse 17 1543 19 36.67 cM Abcc2 ATP-binding cassette, sub-family member 2
Rat 17 1541 1q54 Abcc2 ATP binding cassette subfamily C member 2
Previous and Unofficial Names Click here for help
Canalicular multidrug resistance protein | CMOAT | cMRP | DJS | MRP2 | ATP-binding cassette, sub-family C (CFTR/MRP) member 2 | canalicular multispecific organic anion transporter | multidrug resistance associated protein 2 | multidrug resistance protein 2 | ATP-binding cassette, subfamily C (CFTR/MRP), member 2 | ATP-binding cassette
Database Links Click here for help
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Substrates and Reaction Kinetics Click here for help
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
tenofovir Hs - - 2

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
PAK-104P Small molecule or natural product Hs Inhibition 5.4 pKi 1
pKi 5.4 (Ki 3.7x10-6 M) [1]
Immuno Process Associations
Immuno Process:  Cytokine production & signalling


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1. Chen ZS, Kawabe T, Ono M, Aoki S, Sumizawa T, Furukawa T, Uchiumi T, Wada M, Kuwano M, Akiyama SI. (1999) Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter. Mol Pharmacol, 56 (6): 1219-28. [PMID:10570049]

2. Kalyesubula R, Perazella MA. (2011) Nephrotoxicity of HAART. AIDS Res Treat, 2011: 562790. [PMID:21860787]


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