Abbreviated name: TDF
Synonyms: (R)-PMPA | PMPA | tenofovir (anhydrous)
tenofovir is an approved drug
Compound class:
Synthetic organic
Comment: Tenofovir is a nucleotide reverse transcriptase inhibitor (NtRTI) antiretroviral compound. The R-enantiomer, as shown here, is more effective at inhibiting retroviruses than the S-enantiomer [1]. Tenofovir has poor oral bioavailability and is delivered as either the prodrug tenofovir disoproxil fumarate (Viread®) or tenofovir alafenamide fumerate (Vemlidy®).
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Classification ![]() |
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Compound class | Synthetic organic |
Approved drug? | Yes |
Approved drug? | Yes. |
WHO Essential Medicine | WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version. Click to view more information about the WHO Model Lists of Essential Medicines. |
IUPAC Name ![]() |
[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid |
International Nonproprietary Names ![]() |
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INN number | INN |
7913 | tenofovir |
Synonyms ![]() |
(R)-PMPA | PMPA | tenofovir (anhydrous) |
Database Links ![]() |
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CAS Registry No. | 147127-20-6 (source: Scifinder) |
ChEBI | CHEBI:63625 |
ChEMBL Ligand | CHEMBL483 |
DrugBank Ligand | DB14126 |
DrugCentral Ligand | 2592 |
GtoPdb PubChem SID | 405560389 |
PubChem CID | 464205 |
RCSB PDB Ligand | TFO |
Search Google for chemical match using the InChIKey | SGOIRFVFHAKUTI-ZCFIWIBFSA-N |
Search Google for chemicals with the same backbone | SGOIRFVFHAKUTI |
Search PubMed clinical trials | tenofovir |
Search PubMed titles | tenofovir |
Search PubMed titles/abstracts | tenofovir |
UniChem Compound Search for chemical match using the InChIKey | SGOIRFVFHAKUTI-ZCFIWIBFSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | SGOIRFVFHAKUTI-ZCFIWIBFSA-N |
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Tenofovir (links to external site)
Cat. No. HY-13910 |